ALEXIS Biochemicals: α-Mannosyl Ceramide

ALX-306-031

Revised 23-Sep-08

α-Mannosyl Ceramide
SYNONYMS	α-ManCer
PRODUCT LINE	Immunology
PRODUCT CATEGORY	Natural Killer T [NKT] Cells / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-306-031-C250		250 µg	120.00 USD
ALX-306-031-M001		1 mg	250.00 USD

Product Specification

FORMULA:	C₅₀H₉₉NO₉
MW:	858.3
PURITY:	≥95%
APPEARANCE:	White to brown powder.
SOLUBILITY:	Soluble in pyridine or warm DMSO (4mg/ml).
SHIPPING:	SHIPPED ON BLUE ICE
SHORT TERM STORAGE:	+4°C
LONG TERM STORAGE:	-20°C
HANDLING:	After reconstitution, aliquot into glass vials.

Product Description

Potent stimulator of natural killer T (NKT) cells expressing the invariant Vα19-Jα26 T cell receptor α chain (Vα19 NKT cells).

Product Specific Literature References

Synthetic alpha-mannosyl ceramide as a potent stimulant for an NKT cell repertoire bearing the invariant Valpha19-Jalpha26 TCR alpha chain: N. Okamoto, et al.; Chem. Biol. 12, 677 (2005) Abstract
Induction of promotive rather than suppressive immune responses from a novel NKT cell repertoire Valpha19 NKT cell with alpha-mannosyl ceramide analogues consisting of the immunosuppressant ISP-I as the sphingosine unit: M. Shimamura, et al.; Eur. J. Med. Chem. 41, 569 (2006) Abstract
Modulation of Valpha19 NKT cell immune responses by alpha-mannosyl ceramide derivatives consisting of a series of modified sphingosines: M. Shimamura, et al.; Eur. J. Immunol. 37, 1836 (2007) Abstract

General Information

Natural killer T cells (NKT cells) are important regulators of the immune system. They share properties of both innate as well as adaptive immunity [1]. They express T cell receptors (TCR) on their surface consisting of an invariable α-chain and a somewhat variable β-chain [2]. The majority of NKT cells express the invariable α-chain Vα14-Jα18 (Vα14) in mouse or its homolog in humans Vα24-Jα18 (Vα24) [3]. Vα14 NKT cells recognize α-GalCer presented by CD1d [4, 5].
Recently, NKT cells expressing the invariant Vα19-Jα26 TCR α-chain (Vα19 NKT cells) have been found in peripheral blood lymphocytes and in the liver [6]. They recognize α-ManCer presented by MR1 (Major histocompatibility complex, class I-related) and respond with production of large amounts of immunoregulatory cytokines [7, 8].

General Literature References

[1] Mouse CD1-specific NK1 T cells: development, specificity, and function: A. Bendelac, et al.; Annu. Rev. Immunol. 15, 535 (1997) Abstract
[2] Germline-encoded recognition of diverse glycolipids by natural killer T cells: J.P. Scott-Browne, et al.; Nat. Immunol. 8, 1105 (2007) Abstract
[3] CD1d-restricted mouse V alpha 14 and human V alpha 24 T cells: lymphocytes of innate immunity: K. Benlagha & A. Bendelac; Semin. Immunol. 12, 537 (2000) Abstract
[4] CD1d-restricted and TCR-mediated activation of valpha14 NKT cells by glycosylceramides: T. Kawano, et al.; Science 278, 1626 (1997) Abstract
[5] CD1d-lipid-antigen recognition by the semi-invariant NKT T-cell receptor: N.A. Borg, et al.; Nature 448, 44 (2007) Abstract
[6] Presence of a novel subset of NKT cells bearing an invariant V(alpha)19.1-J(alpha)26 TCR alpha chain: M. Shimamura & Y.Y. Huang; FEBS Lett. 516, 97 (2002) Abstract
[7] Synthetic alpha-mannosyl ceramide as a potent stimulant for an NKT cell repertoire bearing the invariant Valpha19-Jalpha26 TCR alpha chain: N. Okamoto, et al.; Chem. Biol. 12, 677 (2005) Abstract
[8] Modulation of Valpha19 NKT cell immune responses by alpha-mannosyl ceramide derivatives consisting of a series of modified sphingosines: M. Shimamura, et al.; Eur. J. Immunol. 37, 1836 (2007) Abstract

Further Categories Containing This Product:

Ceramides / Cerebrosides / Sphingolipids / Related Products

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