ALEXIS Biochemicals: γ-Secretase Inhibitor

ALX-260-127

Revised 01-Oct-07

γ-Secretase Inhibitor
SYNONYMS	MW167
PRODUCT LINE	Neurobiology
PRODUCT CATEGORY	gamma-Secretase Protein Complex / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-260-127-M001		1 mg	299.00 USD
ALX-260-127-M005		5 mg	1'321.00 USD

Product Specification

FORMULA:	C₃₃H₅₇N₅O₉F₂
MW:	705.8
PURITY:	≥90%
FORMULATION:	Lyophilized.
SOLUBILITY:	Soluble in DMSO containing 10% water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Stock solutions in DMSO are stable for 6 months when stored at -20°C.
HANDLING:	Protect from moisture.

Product Description

Reversible peptidomimetic inhibitor of γ-secretase (IC₅₀=10-25µM for total β-amyloid), presenilinase (IC₅₀=0.1-1µM), and calpain II (IC₅₀=100µM).

Product Specific Literature References

Evidence that the 42- and 40-amino acid forms of amyloid beta protein are generated from the beta-amyloid precursor protein by different protease activities: M. Citron, et al.; PNAS 93, 13170 (1996) Abstract; Full Text
A substrate-based difluoro ketone selectively inhibits Alzheimer's gamma-secretase activity: M.S. Wolfe, et al.; J. Med. Chem. 41, 6 (1998) Abstract
Peptidomimetic probes and molecular modeling suggest that Alzheimer's gamma-secretase is an intramembrane-cleaving aspartyl protease: M.S. Wolfe, et al.; Biochemistry 38, 4720 (1999) Abstract
Presenilin endoproteolysis mediated by an aspartyl protease activity pharmacologically distinct from gamma-secretase: W.A. Campbell, et al.; J. Neurochem. 85, 1563 (2003) Abstract

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