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ALX-630-057 Revised 02-Nov-07
ω-Conotoxin MVIIC
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Neurotoxins
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-630-057-C100   100 µg 340.00 USD Add To Cart
Product Specification
SEQUENCE: H-Cys-Lys-Gly-Lys-Gly-Ala-Pro-Cys-Arg-Lys-Thr-Met-Tyr-Asp-Cys-Cys-Ser-Gly-Ser-Cys-Gly-Arg-Arg-Gly-Lys-Cys-NH2
(Disulfide bonds between Cys1-Cys16, Cys8-Cys20 and Cys15-Cys26)
FORMULA: C106H178N40O32S7
MW: 2749.3
CAS NUMBER: 147794-23-8
SOURCE/HOST: Synthetic. Originally isolated from Conus magus.
QUANTITY:   
PURITY: ≥97%
APPEARANCE: Lyophilized.
SOLUBILITY: Soluble in water.
RECONSTITUTION: Do not remove the cap. Inject distilled water into the vial using a calibrated syringe. Dissolve all contents thoroughly to receive a 0.1mM solution.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for 1 year when stored at -20°C. After reconstitution, stable for up to 2 weeks when stored at +4°C; up to 3 months when stored at -20°C.
HANDLING: After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
HAZARD: POTENT NEUROTOXIN. VERY TOXIC.
Product Description
Neurotoxin. Potent and selective blocker of P/Q-type, voltage-gated Ca2+ channels. Not for sale in U.S.A.
Product Specific Literature References
Conotoxins: B.M. Olivera, et al.; J. Biol. Chem. 266, 22067 (1991), (Minireview) Abstract; Full Text
A new Conus peptide ligand for mammalian presynaptic Ca2+ channels: D.R. Hillyard, et al.; Neuron 9, 69 (1992) Abstract
Calcium channel diversity and neurotransmitter release: the omega-conotoxins and omega-agatoxins: B.M. Olivera, et al.; Ann. Rev. Biochem. 63, 823 (1994), (Review) Abstract
Roles of N-type and Q-type Ca2+ channels in supporting hippocampal synaptic transmission: D.B. Wheeler; Science 264, 107 (1994) Abstract
Inhibition of calcium channels in rat central and peripheral neurons by omega-conotoxin MVIIC: S.I. McDonough, et al.; J. Neurosci. 16, 2612 (1996) Abstract
Structure-activity relationships of omega-conotoxins at N-type voltage-sensitive calcium channels: K.J. Nielsen, et al.; J. Mol. Recognit. 13, 55 (2000), (Review) Abstract
Further Categories Containing This Product:
Ca2+ Channels (P/Q-type) • Peptides
 
 
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