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ALX-550-101 Revised 16-Apr-05
AIDA
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SYNONYMS (±)-1-Aminoindane-1,5-dicarboxylic acid
UPF 523
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Glutamate Receptors (Metabotropic) / Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-550-101-M005   5 mg 35.00 USD Add To Cart
ALX-550-101-M025   25 mg 140.00 USD Add To Cart
Product Specification
FORMULA: C11H11NO4
MW: 221.2
CAS NUMBER: 168560-79-0
PURITY: ≥96%
SOLUBILITY: Soluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Description
Potent and selective ligand for group I mGluRs. Shows no effect on group II or group III mGluRs. Has no effect on ionotropic glutamate receptors.
Product Specific Literature References
1-Aminoindan-1,5-dicarboxylic acid: a novel antagonist at phospholipase C-linked metabotropic glutamate receptors: R. Pellicciari, et al.; J. Med. Chem. 38, 3717 (1995) Abstract
mGluR modulation of post-traumatic neuronal death: role of NMDA receptors: A.G. Mukhin, et al.; Neuroreport 8, 2561 (1997) Abstract
Class I mGlu receptor antagonist 1-aminoindan-1,5-dicarboxylic acid blocks contextual but not cue conditioning in rats: K.S. Nielsen, et al.; Eur. J. Pharmacol. 326, 105 (1997) Abstract
Pharmacological characterization of 1-aminoindan-1,5-dicarboxylic acid, a potent mGluR1 antagonist: F. Moroni, et al.; J. Pharmacol. Exp. Ther. 281, 721 (1997) Abstract
Induction of LTD by activation of group l mGluR in the denate gyrus in vitro: N. Camodeca, et al.; Neuropharmacology 38, 1597 (1999) Abstract
Metabotropic G-protein-coupled glutamate receptors as therapeutic targets: R. Pellicciari & G. Costantino; Curr. Opin. Chem. Biol. 3, 433 (1999), (Review) Abstract
1-Aminoindan-1,5-dicarboxylic acid and (S)-(+)-2-(3'- carboxybicyclo[1.1.1] pentyl)-glycine, two mGlu1 receptor-preferring antagonists, reduce neuronal death in in vitro and in vivo models of cerebral ischaemia: D.E. Pellegrini-Giampietro, et al.; Eur. J. Neurosci. 11, 3637 (1999) Abstract
Evaluation of agonists and antagonists acting at Group I metabotropic glutamate receptors in the thalamus in vivo: T.E. Salt, et al.; Neuropharmacology 38, 1505 (1999) Abstract
Pharmacological agents acting at subtypes of metabotropic glutamate receptors: D.D. Schoepp, et al.; Neuropharmacology 38, 1431 (1999), (Review) Abstract
Further Categories Containing This Product:
Acetylcholine Receptors (Muscarinic) / Related Products
 
 

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