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ALX-270-033 Revised 13-Jul-07
AMT . hydrochloride
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SYNONYMS 2-Amino-5,6-dihydro-6-methyl-4H-1,3-thiazine . HCl
PRODUCT LINE Nitric Oxide Pathway
PRODUCT CATEGORY NOS Inhibitors (NOS Induction & Enzyme Activity)
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-033-M010   10 mg 90.00 USD Add To Cart
ALX-270-033-M050   50 mg 360.00 USD Add To Cart
Product Specification
FORMULA: C5H10N2S . HCl
MW: 130.2 . 36.5
CAS NUMBER: 1121-91-1
PURITY: ≥98%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in water or 100% ethanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HAZARD: IRRITANT.

Product Description
Potent and selective inhibitor of inducible nitric oxide synthase (iNOS/NOS II).
Product Specific Literature References
Novel potent and selective inhibitors of inducible nitric oxide synthase: M. Nakane, et al.; Mol. Pharmacol. 47, 831 (1995) Abstract
In vivo pharmacological evaluation of two novel type II (inducible) nitric oxide synthase inhibitors: W.R. Tracey, et al.; Can. J. Physiol. Pharmacol. 73, 665 (1995) Abstract
Role of inducible nitric oxide synthase in regulation of pulmonary vascular tone in the late gestation ovine fetus: R.L. Rairigh, et al.; J. Clin. Invest. 101, 15 (1998) Abstract
Role of iNOS in the vasodilator responses induced by L-arginine in the middle cerebral artery from normotensive and hypertensive rats: A.M. Briones, et al.; Br. J. Pharmacol. 126, 111 (1999) Abstract
Salt-induced hypertension in Dahl salt-resistant and salt-sensitive rats with NOS II inhibition: M.A. Rudd, et al.; Am. J. Physiol. 277, H732 (1999) Abstract
The inhibitory potency and selectivity of arginine substrate site nitric-oxide synthase inhibitors is solely determined by their affinity toward the different isoenzymes: R. Boer, et al.; Mol. Pharmacol. 58, 1026 (2000) Abstract; Full Text
Inducible nitric oxide synthase inhibition attenuates renal hemodynamics during pregnancy: B.T. Alexander, et al.; Hypertension 39, 586 (2002) Abstract
Potential role of inducible nitric oxide synthase in the sleep-wake states occurrence in old rats: P. Clement, et al.; Neuroscience 135, 347 (2005) Abstract
 
 
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