ALEXIS Biochemicals: AM 1241

ALX-550-383

Revised 11-Apr-07

AM 1241
SYNONYMS	(2-Iodo-5-nitrophenyl)-(1-(1-methylpiperidin-2-ylmethyl)-1H-indol-3-yl)methanone
PRODUCT LINE	Neurobiology
PRODUCT CATEGORY	Cannabinoid Receptor Agonists & Antagonists / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-550-383-M001		1 mg	40.00 USD
ALX-550-383-M005		5 mg	110.00 USD

Product Specification

FORMULA:	C₂₂H₂₂N₃O₃I
MW:	503.3
PURITY:	≥97% (TLC)
APPEARANCE:	Yellow powder.
SOLUBILITY:	Soluble in DMSO, dimethyl formamide, 100% ethanol or methanol; insoluble in water.
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Unstable in 1M NaOH; slightly unstable in 1M HCl.
HANDLING:	Packaged under inert gas. Protect from light.

Product Description

Potent and selective CB₂receptor agonist (K_i=3.4nM (mouse), K_i=280nM (rat) also in vivo.

Product Specific Literature References

CB2 cannabinoid receptor-mediated peripheral antinociception: T.P. Malan, Jr., et al.; Pain 93, 239 (2001) Abstract
Activation of CB2 cannabinoid receptors by AM1241 inhibits experimental neuropathic pain: pain inhibition by receptors not present in the CNS: M.M. Ibrahim, et al.; PNAS 100, 10529 (2003) Abstract; Full Text
Selective activation of cannabinoid CB(2) receptors suppresses spinal fos protein expression and pain behavior in a rat model of inflammation: A.G. Nackley, et al.; Neuroscience 119, 747 (2003) Abstract
Inhibition of inflammatory hyperalgesia by activation of peripheral CB2 cannabinoid receptors: A. Quartilho, et al.; Anesthesiology 99, 955 (2003) Abstract
Selective activation of cannabinoid CB2 receptors suppresses hyperalgesia evoked by intradermal capsaicin: A.G. Hohmann, et al.; J. Pharmacol. Exp. Ther. 308, 446 (2004) Abstract
In vitro pharmacological characterization of AM1241: a protean agonist at the cannabinoid CB2 receptor?: B.B. Yao, et al.; Br. J. Pharmacol. 149, 145 (2006) Abstract

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