ALEXIS Biochemicals: AM 251

ALX-270-239

Revised 19-Jun-08

AM 251
SYNONYMS	N-(Piperidin-1-yl)-5-(4-iodophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide
PRODUCT LINE	Neurobiology
PRODUCT CATEGORY	Cannabinoid Receptor Agonists & Antagonists / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-239-M001		1 mg	29.00 USD
ALX-270-239-M005		5 mg	131.00 USD

Product Specification

FORMULA:	C₂₂H₂₁Cl₂IN₄O
MW:	555.2
CAS NUMBER:	183232-66-8
PURITY:	≥98%
APPEARANCE:	White to light pink solid.
SOLUBILITY:	Soluble in 100% ethanol, DMSO or dimethyl formamide.
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C

Product Description

Structurally related to the cannabinoid receptor (CB) antagonist SR 141716A. Binds with high affinity to cannabinoid receptor CB₁ (K_i=7.49nM; 306-fold selective over CB₂ receptors).

Product Specific Literature References

Binding of the non-classical cannabinoid CP 55,940, and the diarylpyrazole AM251 to rodent brain cannabinoid receptors: S.J. Gatley, et al.; Life Sci. 61, PL 191 (1997) Abstract
Structure-activity relationships of pyrazole derivatives as cannabinoid receptor antagonists: R. Lan, et al.; J. Med. Chem. 42, 769 (1999) Abstract
Inhibition of voltage-sensitive sodium channels by the cannabinoid 1 receptor antagonist AM 251 in mammalian brain: C. Liao, et al.; Basic Clin. Pharmacol. Toxicol. 94, 73 (2004) Abstract
Cannabinoid (CB)1 receptor antagonist, AM 251, causes a sustained reduction of daily food intake in the rat: A.P. Chambers, et al.; Physiol. Behav. 82, 863 (2004) Abstract
The cannabinoid CB1 antagonist AM 251 produces food avoidance and behaviors associated with nausea but does not impair feeding efficiency in rats: P.J. McLaughlin, et al.; Psychopharmacology (Berlin) 180, 286 (2005) Abstract
The cannabinoid 1 receptor antagonist, AM251, prolongs the survival of rats with severe acute pancreatitis: K. Matsuda, et al.; Tohoku J. Exp. Med. 207, 99 (2005) Abstract; Full Text
Anxiogenic profile of AM-251, a selective cannabinoid CB1 receptor antagonist, in plus-maze-naive and plus-maze-experienced mice: R.J. Rodgers, et al.; Behav. Pharmacol. 16, 405 (2005) Abstract
AM 251 produces sustained reductions in food intake and body weight that are resistant to tolerance and conditioned taste aversion: A.P. Chambers, et al.; Br. J. Pharmacol. 147, 109 (2006) Abstract; Full Text

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