ALEXIS Biochemicals: AM 630

ALX-270-241

Revised 03-Mar-05

AM 630
SYNONYMS	(6-Iodo-2-methyl-1-[2-(4-morpholinyl)ethyl]-1H-indol-3-yl)(4-methoxyphenyl)methanone
PRODUCT LINE	Neurobiology
PRODUCT CATEGORY	Cannabinoid Receptor Agonists & Antagonists / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-241-M001		1 mg	20.00 USD
ALX-270-241-M005		5 mg	60.00 USD

Product Specification

FORMULA:	C₂₃H₂₅IN₂O₃
MW:	504.4
CAS NUMBER:	164178-33-0
PURITY:	≥98%
APPEARANCE:	Off-white solid.
SOLUBILITY:	Soluble in DMSO or dimethyl formamide.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C
HANDLING:	Protect from light and oxygen.

Product Description

Competitive CB₁ receptor antagonist in guinea-pig brain. Shows also agonist properties. CB₂ antagonist/inverse agonist (K_i=31.2nM; 165-fold selective over CB₁ receptors).

Product Specific Literature References

AM630, a competitive cannabinoid receptor antagonist: R. Pertwee, et al.; Life Sci. 56, 1949 (1995) Abstract
AM630 is a competitive cannabinoid receptor antagonist in the guinea pig brain: K. Hosohata, et al.; Life Sci. 61, PL115 (1997) Abstract
AM630 antagonism of cannabinoid-stimulated [35S]GTP gamma S binding in the mouse brain: Y. Hosohata, et al.; Eur. J. Pharmacol. 321, R1 (1997) Abstract
AM630 is an inverse agonist at the human cannabinoid CB1 receptor: R.S. Landsman, et al.; Life Sci. 62, PL109 (1998) Abstract
Agonist-inverse agonist characterization at CB1 and CB2 cannabinoid receptors of L759633, L759656, and AM630: R.A. Ross, et al.; Br. J. Pharmacol. 126, 665 (1999) Abstract
Effects of the cannabinoid antagonists AM281 and AM630 on deprivation-induced intake in Lewis rats: N.A. Werner, et al.; Brain Res. 967, 290 (2003) Abstract

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