ALEXIS Biochemicals: AR-A014418

ALX-270-468

Revised 02-Oct-07

AR-A014418
SYNONYMS	N-(4-Methoxybenzyl)-N′-(5-nitro-1,3-thiazol-2-yl)urea
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	GSK-3 Inhibitors

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-468-M001		1 mg	55.00 USD

Product Specification

FORMULA:	C₁₂H₁₂N₄O₄S
MW:	308.3
CAS NUMBER:	487021-52-3
SOURCE/HOST:	Synthetic.
PURITY:	≥95% (HPLC)
APPEARANCE:	White to off-white solid.
SOLUBILITY:	Soluble in DMSO, methanol, 100% ethanol or ethyl acetate.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HANDLING:	Protect from light.
HAZARD:	HARMFUL. MAY BE CARCINOGENIC.
IDENTITY:	Identity determined by ¹H-NMR.

Product Description

Cell permeable, specific and potent inhibitor of glycogen synthase kinase-3 (GSK-3) (IC₅₀=104nM). Inhibition is competitive with respect to ATP (K_i=38nM).

Product Specific Literature References

Structural insights and biological effects of glycogen synthase kinase 3-specific inhibitor AR-A014418: R. Bhat, et al.; J. Biol. Chem. 278, 45937 (2003) Abstract; Full Text
AR-A014418, a selective GSK-3 inhibitor, produces antidepressant-like effects in the forced swim test: T.D. Gould, et al.; Int. J. Neuropsychopharmacol. 7, 387 (2004) Abstract
Inhibition of glycogen synthase kinase-3 by lithium correlates with reduced tauopathy and degeneration in vivo: W. Noble, et al.; PNAS 102, 6990 (2005) Abstract; Full Text

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