ALEXIS Biochemicals: AS601245

ALX-270-443

Revised 05-May-08

AS601245
SYNONYMS	1,3-Benzothiazol-2-yl-(2-{[2-(3-pyridinyl)ethyl]amino}-4-pyrimidinyl) acetonitrile JNK Inhibitor V
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	JNK [SAPK1] / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-443-M001		1 mg	50.00 USD
ALX-270-443-M005		5 mg	150.00 USD
ALX-270-443-M025		25 mg	520.00 USD

Product Specification

FORMULA:	C₂₀H₁₆N₆S
MW:	372.5
CAS NUMBER:	345987-15-7
PURITY:	≥95% (HPLC)
APPEARANCE:	White to yellow solid.
PURITY DETAIL:	Sum of two isomers.
SOLUBILITY:	Soluble in DMSO (10mg/ml).
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Stock solutions are stable for up to 3 months when stored at -20°C.
HANDLING:	Hygroscopic. Packaged under inert gas. Protect from light.
HAZARD:	HARMFUL.
IDENTITY:	Identity determined by ¹H-NMR.

Product Description

Potent and cell permeable ATP competitive JNK inhibitor (hJNK1: IC₅₀=150nM, hJNK2: IC₅₀=220nM and hJNK3: IC₅₀=70 nM). Displays anti-inflammatory properties and has been shown to reduce TNF-α plasma levels induced by LPS in mice.

Product Specific Literature References

AS601245 (1,3-benzothiazol-2-yl (2-[[2-(3-pyridinyl) ethyl] amino]-4 pyrimidinyl) acetonitrile): a c-Jun NH2-terminal protein kinase inhibitor with neuroprotective properties: S. Carboni, et al.; J. Pharmacol. Exp. Ther. 310, 25 (2004) Abstract; Full Text
Design and synthesis of the first generation of novel potent, selective, and in vivo active (benzothiazol-2-yl)acetonitrile inhibitors of the c-Jun N-terminal kinase: P. Gaillard, et al.; J. Med. Chem. 48, 4596 (2005) Abstract

Further Categories Containing This Product:

TNF-alpha & TNF Receptors Other Products • Anti-inflammatory Agents Other Products

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