ALEXIS Biochemicals: Ac-AAVALLPAVLLALLAPDEVD-CHO

ALX-260-046

Revised 06-Jun-08

Ac-AAVALLPAVLLALLAPDEVD-CHO
SYNONYMS	Caspase-3 Inhibitor (Aldehyde)
PRODUCT LINE	Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY	Caspase Inhibitors

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-260-046-M001		1 mg	70.00 USD
ALX-260-046-M005		5 mg	290.00 USD

Product Specification

SEQUENCE:	Ac-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Asp-Glu-Val-Asp-CHO
FORMULA:	C₉₄H₁₅₈N₂₀O₂₇
MW:	2000.4
PEPTIDE CONTENT:	65-95%.
PURITY:	≥95% (HPLC)
APPEARANCE:	White to off-white powder.
FORMULATION:	Lyophilized. TFA salt.
SOLUBILITY:	Soluble in DMSO.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HANDLING:	Keep cool and dry. After dissolving, prepare aliquots and store at -20°C

Product Description

Reversible, cell permeable inhibitor of caspase-3. Also inhibits caspase-6, -7, -8 and -10.

Product Specific Literature References

Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis: W. Nicholson, et al.; Nature 376, 37 (1995) Abstract
Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase: M. Tewari, et al.; Cell 81, 801 (1995) Abstract
Activation of CPP32-like proteases is not sufficient to trigger apoptosis: inhibition of apoptosis by agents that suppress activation of AP24, but not CPP32-like activity: S.C. Wright, et al.; J. Exp. Med. 186, 1107 (1997) Abstract

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