ALEXIS Biochemicals: Ac-DEVD-AMC

ALX-260-031

Revised 02-Mar-06

Ac-DEVD-AMC
SYNONYMS	Caspase-3 Substrate (Fluorogenic)
PRODUCT LINE	Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY	Caspase Substrates

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-260-031-M001		1 mg	40.00 USD
ALX-260-031-M005		5 mg	115.00 USD

Product Specification

SEQUENCE:	Ac-Asp-Glu-Val-Asp-AMC (AMC = 7-Amino-4-methylcoumarin)
FORMULA:	C₃₀H₃₇N₅O₁₃
MW:	675.7
PEPTIDE CONTENT:	70-95%
PURITY:	≥97% (HPLC)
FORMULATION:	Lyophilized.
SOLUBILITY:	Soluble in DMSO. Dilute with buffer, pH 7.5.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HANDLING:	Protect from light.

Product Description

Fluorogenic substrate for caspase-3. Also a substrate for caspase-1, -4, -7 and -8. The peptide sequence is based on the PARP cleavage site Asp²¹⁶for caspase-3.

Product Specific Literature References

Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis: D.W. Nicholson, et al.; Nature 376, 37 (1995) Abstract
Purification and catalytic properties of human caspase family members: M. Garcia-Calvo, et al.; Cell Death Differ. 6, 362 (1999) Abstract

General Information

BACKGROUND/TECHNICAL INFORMATION

AMC has an excitation maximum of 380nm and an emission maximum of 460nm.

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