ALEXIS Biochemicals: Ac-ESMD-CHO

ALX-260-056

Revised 11-Dec-07

Ac-ESMD-CHO
SYNONYMS	Caspase-8 Inhibitor (Aldehyde) Granzyme B Inhibitor (Aldehyde)
PRODUCT LINE	Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY	Caspase Inhibitors

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-260-056-M001		1 mg	83.00 USD
ALX-260-056-M005		5 mg	325.00 USD

Product Specification

SEQUENCE:	Ac-Glu-Ser-Met-Asp-CHO
FORMULA:	C₁₉H₃₀N₄O₁₀S
MW:	506.5
PEPTIDE CONTENT:	70-90%.
PURITY:	≥99% (HPLC)
APPEARANCE:	White powder.
FORMULATION:	Lyophilized.
SOLUBILITY:	Soluble in distilled water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Use always fresh solutions.
HANDLING:	Keep cool and dry. Keep under inert gas.

Product Description

Reversible inhibitor of caspase-8 and granzyme B. Also inhibits caspase-6 and -10. The peptide sequence corresponds to one of the cleavage sites of the inactive 32kDa caspase-3 precursor (aa 25-28). It blocks the formation of the p17 subunit and concomitantly induces the accumulation of the p20 peptide.

Product Specific Literature References

A sequential two-step mechanism for the production of the mature p17:p12 form of caspase-3 in vitro: Z. Han, et al.; J. Biol. Chem. 272, 13432 (1997) Abstract; Full Text

Further Categories Containing This Product:

Granzyme Inhibitors

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