ALEXIS Biochemicals: Ac-IETD-AMC

ALX-260-042

Revised 02-Oct-07

Ac-IETD-AMC
SYNONYMS	Caspase-8 Substrate (Fluorogenic) Granzyme B Substrate (Fluorogenic)
PRODUCT LINE	Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY	Caspase Substrates

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-260-042-M001		1 mg	42.00 USD
ALX-260-042-M005		5 mg	163.00 USD

Product Specification

SEQUENCE:	Ac-Ile-Glu-Thr-Asp-AMC (AMC=7-Amino-4-methylcoumarin)
FORMULA:	C₃₁H₄₁N₅O₁₂
MW:	675.7
PEPTIDE CONTENT:	70-90%
PURITY:	≥98% (HPLC)
FORMULATION:	Lyophilized.
SOLUBILITY:	Soluble in DMSO. Dilute with buffer, pH 7.5.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C

Product Description

Fluorogenic substrate for caspase-8 and granzyme B. Also a substrate for caspase-10.

Product Specific Literature References

Bid truncation, bid/bax targeting to the mitochondria, and caspase activation associated with neutrophil apoptosis are inhibited by granulocyte colony-stimulating factor: N.A. Maianski, et al.; J. Immunol. 172, 7024 (2004) Abstract

General Information

BACKGROUND/TECHNICAL INFORMATION

AMC has an excitation maximum of 380nm and an emission maximum of 460nm.

Further Categories Containing This Product:

Granzyme Substrates

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