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ALX-260-064 Revised 17-Jan-06
Ac-VEID-AMC
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SYNONYMS Caspase-6 Substrate (Fluorogenic)
PRODUCT LINE Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY Caspase Substrates
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-260-064-M001   1 mg 32.00 USD Add To Cart
ALX-260-064-M005   5 mg 123.00 USD Add To Cart
Product Specification
SEQUENCE: Ac-Val-Glu-Ile-Asp-AMC (AMC=7-Amino-4-methylcoumarin)
FORMULA: C32H43N5O11
MW: 673.8
PEPTIDE CONTENT: 70-90%
PURITY: ≥98% (HPLC)
APPEARANCE: White powder.
SOLUBILITY: Soluble in DMSO. Dilute with distilled water or buffer. Also soluble in phosphate buffer, pH 7.5.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
HANDLING: Keep cool and dry.
Product Description
Fluorogenic substrate for caspase-6.
Product Specific Literature References
Cleavage of lamin A by Mch2alpha but not CPP32: multiple interleukin 1beta-converting enzyme-related proteases with distinct substrate recognition properties are active in apoptosis: A. Takahashi, et al.; PNAS 93, 8395 (1996) Abstract
Activation of multiple interleukin-1β converting enzyme homologues in cytosol and nuclei of HL-60 cells during etoposide-induced apoptosis: L.M. Martins, et al.; J. Biol. Chem. 272, 7421 (1997) Abstract; Full Text
Apoptosis by death factor: S. Nagata; Cell 88, 355 (1997) Abstract
Substrate specificities of caspase family proteases: R.V. Talanian, et al.; J. Biol. Chem. 272, 9677 (1997) Abstract; Full Text
A combinatorial approach defines specificities of members of the caspase family and granzyme B: N.A. Thornberry, et al.; J. Biol. Chem. 272, 17907 (1997) Abstract; Full Text
Purification and catalytic properties of human caspase family members: M. Garcia-Calvo, et al.; Cell Death Differ. 6, 362 (1999) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION AMC has an excitation maximum of 380nm and an emission maximum of 460nm.
 
 
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