ALEXIS Biochemicals: Ac-WEHD-AMC

ALX-260-057

Revised 25-Sep-07

Ac-WEHD-AMC
SYNONYMS	Caspase-1 Substrate (Fluorogenic) Caspase-5 Substrate (Fluorogenic)
PRODUCT LINE	Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY	Caspase Substrates

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-260-057-M001		1 mg	42.00 USD
ALX-260-057-M005		5 mg	123.00 USD

Product Specification

SEQUENCE:	Ac-Trp-Glu-His-Asp-AMC (AMC=7-Amino-4-methylcoumarin)
FORMULA:	C₃₈H₄₀N₈O₁₁
MW:	784.8
PEPTIDE CONTENT:	70-90%
PURITY:	≥99% (HPLC)
FORMULATION:	Lyophilized.
SOLUBILITY:	Soluble in DMSO. Dilute with distilled water or buffer.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HANDLING:	Protect from light and moisture.

Product Description

Fluorogenic substrate for caspase-1 and -5. Also a substrate for caspase-4. This fluorogenic caspase-1 substrate with an optimal tetrapeptide sequence is cleaved 50-fold more efficiently than Ac-YVAD-AMC (Prod. No. ALX-260-024).

Product Specific Literature References

A combinatorial approach defines specificities of members of the caspase family and granzyme B: N.A. Thornberry, et al.; J. Biol. Chem. 272, 17907 (1997) Abstract; Full Text

General Information

BACKGROUND/TECHNICAL INFORMATION

AMC has an excitation maximum of 380nm and an emission maximum of 460nm.

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