ALEXIS Biochemicals: Ac-WEHD-CHO

ALX-260-055

Revised 23-Feb-07

Ac-WEHD-CHO
SYNONYMS	Caspase-1 Inhibitor (Aldehyde) Caspase-5 Inhibitor (Aldehyde)
PRODUCT LINE	Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY	Caspase Inhibitors

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-260-055-M001		1 mg	97.00 USD
ALX-260-055-M005		5 mg	385.00 USD

Product Specification

SEQUENCE:	Ac-Trp-Glu-His-Asp-CHO
FORMULA:	C₂₈H₃₃N₇O₉
MW:	611.6
PURITY:	≥90% (HPLC)
APPEARANCE:	White to off-white powder.
FORMULATION:	TFA salt.
SOLUBILITY:	Soluble in water (10mg/ml).
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Solution is stable for 1 month when stored at -20°C and protected from light.
HANDLING:	Keep cool and dry.

Product Description

Reversible, cell permeable inhibitor of caspase-1 and -5. Also inhibits caspase-4.

Product Specific Literature References

A combinatorial approach for determining protease specificities: application to interleukin-1beta converting enzyme (ICE): T.A. Rano, et al.; Chem. Biol. 4, 149 (1997) Abstract
A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis: N.A. Thornberry, et al.; J. Biol. Chem. 272, 17907 (1997) Abstract; Full Text

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