ALEXIS Biochemicals: Ac-YVAD-AFC

ALX-260-108

Revised 03-Jun-05

Ac-YVAD-AFC
SYNONYMS	Caspase-1 Substrate (Fluorogenic) Caspase-4 Substrate (Fluorogenic)
PRODUCT LINE	Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY	Caspase Substrates

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-260-108-M005		5 mg	147.00 USD
ALX-260-108-M010		10 mg	275.00 USD

Product Specification

SEQUENCE:	Ac-Tyr-Val-Ala-Asp-AFC (AFC=7-Amino-4-trifluoromethylcoumarin)
FORMULA:	C₃₃H₃₆F₃N₅O₁₀
MW:	719.7
PURITY:	≥99% (HPLC)
APPEARANCE:	White to off-white powder.
SOLUBILITY:	Soluble in DMSO.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Solid product is stable for 1 year in desiccator when stored at room temperature. Stock solutions are stable for 6 – 8 months when stored at –20°C. Keep sealed after removing from the freezer until its temperature equilibrates with room temperature.
HANDLING:	Keep cool and dry.

Product Description

Fluorogenic substrate for caspase-1 and -4.

Product Specific Literature References

Caspase-7 is activated during lovastatin-induced apoptosis of the prostate cancer cell line LNCaP: M. Marcelli, et al.; Cancer Res. 58, 76 (1998) Abstract

General Information

BACKGROUND/TECHNICAL INFORMATION

AFC has an excitation maximum of 400nm and an emission maximum of 505nm.

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