ALEXIS Biochemicals: Ac-YVAD-AMC

ALX-260-024

Revised 17-Jan-06

Ac-YVAD-AMC
SYNONYMS	Caspase-1 Substrate (Fluorogenic)
PRODUCT LINE	Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY	Caspase Substrates

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-260-024-M001		1 mg	37.00 USD
ALX-260-024-M005		5 mg	98.00 USD

Product Specification

SEQUENCE:	Ac-Tyr-Val-Ala-Asp-AMC (AMC = 7-Amino-4-methylcoumarin)
FORMULA:	C₃₃H₃₉N₅O₁₀
MW:	665.7
PEPTIDE CONTENT:	75-95%
PURITY:	≥99% (HPLC)
APPEARANCE:	White to off-white powder.
SOLUBILITY:	Soluble in DMSO. Dilute with distilled water or buffer, pH 7.0-7.5 (e. g. TRIS, HEPES).
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HANDLING:	Keep cool and dry.

Product Description

Fluorogenic substrate for caspase-1.

Product Specific Literature References

A novel heterodimeric cysteine protease is required for interleukin-1 β processing in monocytes: N.A. Thornberry, et al.; Nature 356, 768 (1992) Abstract
Interleukin-1 β converting enzyme: N.A. Thornberry; Meth. Enzymol. 244, 615 (1994) Abstract
Crystal structure of the cysteine protease interleukin-1 β-converting enzyme: a (p20/p10)2 homodimer: N.P.C. Walker, et al.; Cell 78, 343 (1994) Abstract

General Information

BACKGROUND/TECHNICAL INFORMATION

AMC has an excitation maximum of 380nm and an emission maximum of 460nm.

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