ALEXIS Biochemicals: Ac-YVAD-CHO

ALX-260-027

Revised 03-May-07

Ac-YVAD-CHO
SYNONYMS	Caspase-1 Inhibitor (Aldehyde)
PRODUCT LINE	Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY	Caspase Inhibitors

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-260-027-M001		1 mg	42.00 USD
ALX-260-027-M005		5 mg	163.00 USD

Product Specification

SEQUENCE:	Ac-Tyr-Val-Ala-Asp-CHO
FORMULA:	C₂₃H₃₂N₄O₈
MW:	492.5
PEPTIDE CONTENT:	70-90%
PURITY:	≥96% (HPLC)
APPEARANCE:	White powder.
FORMULATION:	Lyophilized. TFA salt.
SOLUBILITY:	Soluble in DMSO or water.
RECONSTITUTION:	Add 0.2ml DMSO per 1.0mg peptide. Shake well until all the contents are dissolved. This furnishes a 10mM solution of this material.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Stock solutions should be divided into aliquots and stored at -20°C.
HANDLING:	Keep cool and dry. Keep under inert gas.

Product Description

Potent and reversible inhibitor of caspase-1. Also inhibits caspase-4. Strongly inhibits anti-Fas induced apoptosis in L929-Fas cells.

Product Specific Literature References

K.T. Chapman; Bioorg. Med. Chem. Lett. 2, 613 (1992)
A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes: N.A. Thornberry, et al.; Nature 356, 768 (1992) Abstract
Interleukin 1 β (IL-1 β) processing in murine macrophages requires a structurally conserved homologue of human IL-1 β converting enzyme: S.M. Molineaux, et al.; PNAS 90, 1809 (1993) Abstract
Crystal structure of the cysteine protease interleukin-1 beta- converting enzyme: a (p20/p10)2 homodimer: N.P.C. Walker, et al.; Cell 78, 343 (1994) Abstract
Structure and mechanism of interleukin-1 β converting enzyme: K.P. Wilson, et al.; Nature 370, 270 (1994) Abstract
Requirement of an ICE/CED-3 protease for Fas/APO-1-mediated apoptosis: M. Los, et al.; Nature 375, 81 (1995) Abstract
Peptide inhibitors of the ICE protease family arrest programmed cell death of motoneurons in vivo and in vitro: C.E. Milligan, et al.; Neuron 15, 385 (1995) Abstract
Sequential activation of ICE-like and CPP32-like proteases during Fas- mediated apoptosis: M. Enari, et al.; Nature 380, 723 (1996) Abstract
Role of the nuclear localization sequence in fibroblast growth factor-1-stimulated mitogenic pathways: Y.Z. Lin, et al.; J. Biol. Chem. 271, 3505 (1996) Abstract; Full Text
Inhibition of human caspases by peptide-based and macromolecular inhibitors: M. Garcia-Calvo, et al.; J. Biol. Chem. 273, 32608 (1998) Abstract; Full Text

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