ALEXIS Biochemicals: Ac-YVAD-CMK

ALX-260-028

Revised 27-Mar-08

Ac-YVAD-CMK
SYNONYMS	Caspase-1 Inhibitor (Chloromethylketone)
PRODUCT LINE	Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY	Caspase Inhibitors

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-260-028-M001		1 mg	55.00 USD
ALX-260-028-M005		5 mg	220.00 USD

Product Specification

SEQUENCE:	Ac-Tyr-Val-Ala-Asp-chloromethylketone
FORMULA:	C₂₄H₃₃N₄O₈Cl
MW:	541.0
PURITY:	≥96% (HPLC)
APPEARANCE:	White to off-white powder.
SOLUBILITY:	Soluble in DMSO (50mg/ml).
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Stock solutions should be divided into aliquots and stored at -20°C.

Product Description

Irreversible, cell permeable inhibitor of caspase-1. Also inhibits caspase-4. Inhibits Fas-mediated apoptosis.

Product Specific Literature References

Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE: Y.A. Lazebnik, et al.; Nature 371, 346 (1994) Abstract
Crystal structure of the cysteine protease interleukin-1 beta- converting enzyme: a (p20/p10)2 homodimer: N.P.C. Walker, et al.; Cell 78, 343 (1994) Abstract
Involvement of an ICE-like protease in Fas-mediated apoptosis: M. Enari, et al.; Nature 375, 78 (1995)
Involvement of interleukin-1 beta-converting enzyme in apoptosis of bFGF-deprived murine aortic endothelial cells: S. Kondo, et al.; FASEB J. 10, 1192 (1996) Abstract
Peptide inhibitors of the ICE protease family arrest programmed cell death of motoneurons in vivo and in vitro: C.E. Milligan, et al.; Neuron 15, 385 (1995) Abstract
Sequential activation of ICE-like and CPP32-like proteases during Fas- mediated apoptosis: M. Enari, et al.; Nature 380, 723 (1996) Abstract
ICE inhibitor YVADcmk is a potent therapeutic agent against in vivo liver apoptosis: N. Rouquet, et al.; Curr. Biol. 6, 1192 (1996) Abstract
Caspase-1-inhibitor ac-YVAD-cmk reduces LPS-lethality in rats without affecting haematology or cytokine responses: G. Mathiak, et al.; Br. J. Pharmacol. 131, 383 (2000) Abstract

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