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ALX-480-012 Revised 27-Apr-06
Adenosine 3',5'-cyclic Monophosphothioate, Rp-Isomer . triethylammonium salt
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SYNONYMS Rp-cAMPS . TEA
cAMPS . TEA, Rp-Isomer
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY cAMP Derivatives
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-480-012-M001   1 mg 110.00 USD Add To Cart
ALX-480-012-M005   5 mg 460.00 USD Add To Cart
Product Specification
FORMULA: C10H12N5O5PS . C6H16N
MW: 345.5 . 101.0
CAS NUMBER: 151837-09-1
PURITY: ≥99%
APPEARANCE: White lyophilized solid.
SOLUBILITY: Soluble in water
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Competitive inhibitor of protein cAMP-dependent protein kinase type I and II (cAMP antagonist). Resistant against mammalian cyclic nucleotide-dependent phosphodiesterases. Significantly more lipophilic as compared to cAMP and thus membrane permeable in many biological systems.
Product Specific Literature References
A mechanistic and kinetic analysis of the interactions of the diastereoisomers of adenosine 3',5'-(cyclic)phosphorothioate with purified cyclic AMP-dependent protein kinase: J.D. Rothermel; Biochem. J. 251, 757 (1988) Abstract
Probing the cyclic nucleotide binding sites of cAMP-dependent protein kinases I and II with analogs of adenosine 3',5'-cyclic phosphorothioates: W.R.G. Dostmann, et al.; J. Biol. Chem. 265, 10484 (1990) Abstract; Full Text
Inhibition of cGMP-dependent protein kinase by (Rp)-guanosine 3',5'- monophosphorothioates: E. Butt, et al.; FEBS Lett. 263, 47 (1990) Abstract
Regulation of kainate receptors by cAMP-dependent protein kinase and phosphatases: L.Y. Wang, et al.; Science 253, 1132 (1991) Abstract
Stimulation of the ERK pathway by GTP-loaded Rap1 requires the concomitant activation of Ras, protein kinase C, and protein kinase A in neuronal cells: T. Bouschet, et al.; J. Biol. Chem. 278, 4778 (2003) Abstract; Full Text
Further Categories Containing This Product:
PKA Inhibitors
 
 
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