ALEXIS Biochemicals: Aflatoxin B1

ALX-630-093

Revised 23-Jul-08

Aflatoxin B1
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Mycotoxins

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-630-093-M001		1 mg	28.00 USD
ALX-630-093-M005		5 mg	110.00 USD

Product Specification

FORMULA:	C₁₇H₁₂O₆
MW:	312.3
CAS NUMBER:	1162-65-8
MERCK INDEX:	14: 180
RTECS:	GY1925000
SOURCE/HOST:	Isolated from Aspergillus flavus.
PURITY:	≥98% (HPLC)
APPEARANCE:	White to yellow powder.
SOLUBILITY:	Soluble in DMSO (20mg/ml) or methylene chloride (10mg/ml).
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C
HAZARD:	VERY TOXIC. MAY BE CARCINOGENIC. MAY BE TERATOGENIC.

Product Description

Naturally occuring mycotoxin produced by many species of Aspergillus. Metabolized by the liver to the reactive intermediate aflatoxin M₁. Exposure may produce acute necrosis, cirrhosis and carcinoma of the liver. Induces DNA damage.

Product Specific Literature References

Molecular dosimetry of aflatoxin exposure: contribution to understanding the multifactorial etiopathogenesis of primary hepatocellular carcinoma with particular reference to hepatitis B virus: C.P. Wild, et al.; Environ. Health Perspect. 99, 115 (1993) Abstract
A follow-up study of urinary markers of aflatoxin exposure and liver cancer risk in Shanghai, People's Republic of China: G.S. Qian, et al.; Cancer Epidemiol. Biomarkers Prev. 3, 3 (1994) Abstract
Aflatoxin B1 induced lacI mutation in liver and kidney of transgenic mice C57BL/6N: effect of phorone: H. Autrup, et al.; Mutagenesis 11, 69 (1996) Abstract
Activation and detoxication of aflatoxin B1: F.P. Guengerich, et al.; Mutat. Res. 402, 121 (1998), (Review) Abstract
Hyperplasia, partial hepatectomy, and the carcinogenicity of aflatoxin B1: B.D. Roebu; J. Cell. Biochem. 91, 242 (2004), (Review) Abstract
Aflatoxin B1-induced DNA damage and its repair: L. L. Bedard & T. E. Massey; Cancer Lett. 241, 174 (2006), (Review) Abstract

General Information

Not for sale in U. S. A.

Further Categories Containing This Product:

Carcinogens & Tumor Promoters Other Products • Natural Products - Plant Research Reagents • Natural Products - Other Tumor Promoters • Plant Research Reagents / Related Products • Non-apoptotic Cell Death / Necrosis

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