ALEXIS Biochemicals: Aloisine

ALX-270-386

Revised 24-Feb-05

Aloisine
SYNONYMS	RP106 7-n-Butyl-6-(4-methoxyphenyl)[5H]pyrrolo[2,3-b]pyrazine
PRODUCT LINE	Cell Cycle
PRODUCT CATEGORY	CDK & Cyclin Inhibitors

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-386-M001		1 mg	25.00 USD

Product Specification

FORMULA:	C₁₇H₁₉N₃O
MW:	281.4
PURITY:	≥95%
APPEARANCE:	Off-white solid.
SOLUBILITY:	Soluble in DMSO or methanol.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C
HANDLING:	Protect from light. Packaged under inert gas.

Product Description

Potent, cell permeable, selective ATP-competitive inhibitor of CDK1/cyclin B (IC₅₀=700nM), CDK5/p25 (IC₅₀=1.5µM), and GSK-3 (IC₅₀=920nM).

Product Specific Literature References

Aloisines, a new family of CDK/GSK-3 inhibitors. SAR study, crystal structure in complex with CDK2, enzyme selectivity, and cellular effects: Y. Mettey, et al.; J. Med. Chem. 46, 222 (2003) Abstract

Further Categories Containing This Product:

GSK-3 Inhibitors • Cell Cycle Blockers & Inhibitors/Related Products

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