ALEXIS Biochemicals: Aloisine A

ALX-270-385

Revised 17-Jul-07

Aloisine A
SYNONYMS	RP107 7-n-Butyl-6-(4-hydroxyphenyl)[5H]pyrrolo[2,3-b]pyrazine
PRODUCT LINE	Cell Cycle
PRODUCT CATEGORY	CDK & Cyclin Inhibitors

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-385-M001		1 mg	30.00 USD

Product Specification

FORMULA:	C₁₆H₁₇N₃O
MW:	267.3
PURITY:	≥95%
APPEARANCE:	Yellow solid.
SOLUBILITY:	Soluble in DMSO.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HANDLING:	Protect from light. Packaged under inert gas.

Product Description

Cell permeable, potent, selective, reversible and ATP-competitive inhibitor of CDK1/cyclin B (IC₅₀=150nM), CDK2/cyclin A (IC₅₀=120nM), CDK2/cyclin E (IC₅₀=400nM), CDK5/p25
(IC₅₀=200nM), CDK5/p35 (IC₅₀=160nM) and GSK-3α (IC₅₀=500nM). Also inhibits GSK-3β (IC₅₀=650nM) and c-Jun N-terminal kinase (JNK) (IC₅₀~3-10µM). Poor inhibitor of CK1, CK2, CDK4/cyclin D1, MAPKK, PKA, PKG, PKCs and c-raf (IC₅₀≥100µM). Blocks cell cycle in both G1 and G2 phase.

Product Specific Literature References

Aloisines, a new family of CDK/GSK-3 inhibitors. SAR study, crystal structure in complex with CDK2, enzyme selectivity, and cellular effects: Y. Mettey, et al.; J. Med. Chem. 46, 222 (2003) Abstract

Further Categories Containing This Product:

GSK-3 Inhibitors • JNK [SAPK1] / Related Products • Cell Cycle Blockers & Inhibitors / Related Products

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