ALEXIS Biochemicals: Amastatin . hydrochloride

ALX-260-003

Revised 09-May-07

Amastatin . hydrochloride
SYNONYMS	[(2S,3R)-3-Amino-2-hydroxy-5-methyl-hexanoyl]-Val-Val-Asp-OH . HCl
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	Aminopeptidases / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-260-003-M001		1 mg	73.00 USD
ALX-260-003-M005		5 mg	235.00 USD

Product Specification

FORMULA:	C₂₁H₃₈N₄O₈. HCl
MW:	474.6 . 36.5
CAS NUMBER:	100938-10-1
SOURCE/HOST:	Synthetic.
PURITY:	≥98%
APPEARANCE:	White to off-white powder.
SOLUBILITY:	Soluble in acetic acid.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C

Product Description

Competitive inhibitor of human serum aminopeptidase A, pig kidney leucine aminopeptidase, leucine aminopeptidase, tyrosine aminopeptidase, but not of aminopeptidase B. Has been used to potentiate the action of some bioactive peptides by inhibiting their degradation by aminopeptidases.

Product Specific Literature References

Amastatin, an inhibitor of aminopeptidase A, produced by actinomycetes: T. Aoyagi, et al.; J. Antibiot. (Tokyo) 31, 636 (1978) Abstract
H. Tobe, et al.; Agric. Biol. Chem. 43, 591 (1979)
Inhibition of aminopeptidases by amastatin and bestatin derivatives. Effect of inhibitor structure on slow-binding processes: D.H. Rich, et al.; J. Med. Chem. 27, 417 (1984) Abstract

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