ALEXIS Biochemicals: Amiloride, 5-(N-Methyl-N-isobutyl)-

ALX-550-257

Revised 10-Feb-05

Amiloride, 5-(N-Methyl-N-isobutyl)-
SYNONYMS	5-(N-Methyl-N-isobutyl)amiloride MIA
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	Na+ Channels

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-550-257-M005		5 mg	25.00 USD

Product Specification

FORMULA:	C₁₁H₁₈ClN₇O
MW:	299.8
CAS NUMBER:	96861-65-3
PURITY:	≥98%
APPEARANCE:	Yellow solid.
SOLUBILITY:	Soluble in dilute aqueous acid or DMSO; insoluble in water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C
HANDLING:	Protect from light.

Product Description

Potent inhibitor of the Na⁺/H⁺ antiporter. Possible antitumor agent.

Product Specific Literature References

Interactions of chloride and amiloride with the renal Na+/H/ antiporter: D.G. Warnock, et al.; J. Biol. Chem. 263, 7216 (1988) Abstract; Full Text
Methyl isobutyl amiloride: a new probe to assess the number of Na-H antiporters: Z. Talor, et al.; Life Sci. 45, 517 (1989) Abstract
Therapeutic potential of analogues of amiloride: inhibition of the regulation of intracellular pH as a possible mechanism of tumour selective therapy: R.P. Maidorn, et al.; Br. J. Cancer. 67, 297 (1993) Abstract
Study of fibroblast spreading: pH dependence, involvement of the Na+/H(+)-antiporter and PKC: I.Y. Novikova, et al.; Biochim. Biophys. Acta 1178, 267 (1993) Abstract
Methyl isobutyl amiloride alters regional brain reperfusion after resuscitation from cardiac arrest in rats: K.L. Lauro, et al.; Brain Res. 831, 64 (1999) Abstract
Role of Na(+)/H(+) exchanger during ischemia and preconditioning in the isolated rat heart: X.H. Xiao & D.G. Allen; Circ. Res. 85, 723 (1999) Abstract

Further Categories Containing This Product:

Imidazoline Binding Site Ligands • Ca2+ Channels (T-type) • Antitumor Reagents Other Products

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