ALEXIS Biochemicals: Amiloride, 5-(N,N-Dimethyl)-, . hydrochloride

ALX-550-261

Revised 16-Apr-05

Amiloride, 5-(N,N-Dimethyl)-, . hydrochloride
SYNONYMS	5-(N,N-Dimethyl)amiloride . HCl DMA . HCl
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	Na+ Channels

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-550-261-M005		5 mg	30.00 USD

Product Specification

FORMULA:	C₈H₁₂ClN₇O . HCl
MW:	257.7 . 36.5
CAS NUMBER:	1214-79-5 (free base)
PURITY:	≥98%
APPEARANCE:	Yellow solid.
SOLUBILITY:	Soluble in methanol (10mg/ml) or water (6mg/ml).
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C
HANDLING:	Protect from light.

Product Description

Na⁺/H⁺antiporter inhibitor (IC₅₀=6.9 µM) with increased selectivity and potency relative to amiloride (Prod. No. ALX-550-212).

Product Specific Literature References

Involvement of sodium in the protective effect of 5-(N,N-dimethyl)- amiloride on ischemia-reperfusion injury in isolated rat ventricular wall: H. Meng & G.N. Pierce; J. Pharmacol. Exp. Ther. 256, 1094 (1991) Abstract
Amiloride and its analogs as tools in the study of ion transport: T.R. Kleyman & E.J. Cragoe Jr.; J. Membr. Biol. 105, 1 (1988) Abstract
Effect of 5-(N,N-Dimethyl)-amiloride, a specific inhibitor of Na(+)/H(+) exchanger, on the palmitoyl-L-carnitine-induced mechanical and metabolic derangements in the isolated perfused rat heart: J. Arakawa & A. Hara; Pharmacology 59, 239 (1999) Abstract
Hypericin-induced phototoxicity of human leukemic cell line HL-60 is potentiated by omeprazole, an inhibitor of H+K+-ATPase and 5'-(N,N-dimethyl)-amiloride, an inhibitor of Na+/H+ exchanger: L. Mirossay, et al.; Physiol. Res. 48, 135 (1999) Abstract

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Imidazoline Binding Site Ligands • Ca2+ Channels (T-type)

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