ALEXIS Biochemicals: Aminopurvalanol A

ALX-270-249

Revised 11-Sep-08

Aminopurvalanol A
SYNONYMS	(2R)-2-((6-((3-Amino-5-chlorophenyl)amino)-9-(1-methylethyl)- 9H-purin-2-yl)amino)-3-methyl-1-butanol NG-97
PRODUCT LINE	Cell Cycle
PRODUCT CATEGORY	CDK & Cyclin Inhibitors

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-249-M001		1 mg	45.00 USD
ALX-270-249-M005		5 mg	135.00 USD

Product Specification

FORMULA:	C₁₉H₂₆N₇OCl
MW:	403.9
CAS NUMBER:	220792-57-4
PURITY:	≥97% (¹H-NMR)
APPEARANCE:	White to brownish solid.
SOLUBILITY:	Soluble in DMSO or methanol.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C
HANDLING:	Packaged under inert gas. Protect from light.
HAZARD:	IRRITANT.

Product Description

Cell permeable, reversible and competitive inhibitor of CDK1/cyclin B (IC₅₀=33nM), CDK2/cyclin A (IC₅₀=33nM), CDK2/cyclin E (IC₅₀=28nM) and CDK5/p35 (IC₅₀=20nM).

Product Specific Literature References

Synthesis and application of functionally diverse 2,6,9-trisubstituted purine libraries as CDK inhibitors: Y.T. Chang, et al.; Chem. Biol. 6, 361 (1999) Abstract
A cyclin-dependent kinase inhibitor inducing cancer cell differentiation: biochemical identification using Xenopus egg extracts: G.R. Rosania, et al.; PNAS 96, 4797 (1999) Abstract; Full Text
M-phase regulation of the recruitment of mRNAs onto polysomes using the CDK1/cyclin B inhibitor aminopurvalanol: M. Le Breton, et al.; BBRC 306, 880 (2003) Abstract

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