ALEXIS Biochemicals: Ampicillin . sodium salt

ALX-380-268

Revised 21-May-08

Ampicillin . sodium salt
SYNONYMS	D-(−)-α-Aminobenzylpenicillin . Na
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Antibiotics Other Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-380-268-G005		5 g	45.00 USD

Product Specification

FORMULA:	C₁₆H₁₈N₃O₄S . Na
MW:	348.4 . 23.0
CAS NUMBER:	69-52-3
MERCK INDEX:	14: 586
RTECS:	XH8400000
SOURCE/HOST:	Semisynthetic from penicillin.
PURITY:	≥95% (Assay)
APPEARANCE:	White to light yellow powder.
SOLUBILITY:	Soluble in water (50mg/ml).
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HAZARD:	IRRITANT.

Product Description

β-Lactam antibiotic. Inhibits bacterial cell-wall synthesis (peptidoglycan cross-linking). Inactivates transpeptidases on the inner surface of the bacterial cell membrane. Effective against Gram-negative and Gram-positive bacteria. Is inactivated by β-lactamase.

Product Specific Literature References

7-substituted actinomycin D analogs. Chemical and growth-inhibitory studies: J. Med. Chem.; S.K. Sengupta, et al. 18, 1175 (1975) Abstract
N7-Substituted 7-aminoactinomycin D analogues. Synthesis and biological properties: M.S. Madhavarao, et al.; J. Med. Chem. 21, 958 (1978) Abstract
Sulbactam/ampicillin. A review of its antibacterial activity, pharmacokinetic properties, and therapeutic use: D.M. Campoli-Richards & R.N. Brogden; Drugs 33, 577 (1987) Abstract
Induction of apoptosis (programmed cell death) in human leukemic HL-60 cells by inhibition of RNA or protein synthesis: S.J. Martin, et al.; J. Immunol. 145, 1859 (1990) Abstract
Short exposure to actinomycin D induces "reversible" translocation of protein B23 as well as "reversible" inhibition of cell growth and RNA synthesis in HeLa cells: B.Y. Yung, et al.; Cancer Res. 50, 5987 (1990) Abstract
Schedule-dependent effects of two consecutive, divided, low doses of actinomycin D on translocation of protein B23, inhibition of cell growth and RNA synthesis in HeLa cells: B.Y. Yung, et al.; Int. J. Cancer 52, 317 (1992) Abstract
Nerve growth factor and epidermal growth factor rescue PC12 cells from programmed cell death induced by etoposide: distinct modes of protection against cell death by growth factors and a protein-synthesis inhibitor: M. Nakajima, et al.; Neurosci. Lett. 176, 161 (1994) Abstract

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