ALEXIS Biochemicals: Ansatrienin B

ALX-380-204

Revised 19-Mar-08

Ansatrienin B
SYNONYMS	Mycotrienin II T 23II
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Antitumor Antibiotics

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-380-204-M001		1 mg	380.00 USD

Product Specification

FORMULA:	C₃₆H₅₀N₂O₈
MW:	638.8
CAS NUMBER:	82189-04-6
RTECS:	AY4553430
SOURCE/HOST:	Isolated from Streptomyces sp. MST-AS5998.
PURITY:	≥95% (HPLC)
APPEARANCE:	Yellow powder.
SOLUBILITY:	Soluble in 100% methanol, methanol, dimethyl formamide or DMSO.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HANDLING:	Protect from light.
HAZARD:	TOXIC.

Product Description

Antitumor antibiotic, closely related to the cytotrienins. Displays potent anti-cancer activities. Significantly potentiates the action of several clinical anti-tumor agents. Inhibits osteoclastic bone resorption.

Product Specific Literature References

Mycotrienin, a new polyene antibiotic isolated from Streptomyces: C. Coronelli, et al.; J. Antibiot. (Tokyo) 20, 329 (1967) Abstract
Studies on mycotrienin antibiotics, a novel class of ansamycins. I. Taxonomy, fermentation, isolation and properties of mycotrienins I and II: M. Sugita, et al.; J. Antibiot. (Tokyo) 35, 1460 (1982) Abstract
Studies on mycotrienin antibiotics, a novel class of ansamycins. II. Structure elucidation and biosynthesis of mycotrienins I and II: M. Sugita, et al.; J. Antibiot. (Tokyo) 35, 1467 (1982) Abstract
Potentiation of mitomycin C, 6-mercaptopurine, bleomycin, cis-diamminedichloroplatinum and 5-fluorouracil by mycotrienins and mycotrienols: M. Kuwano, et al.; Gann. 74, 759 (1983) Abstract
Mycotrienins. A new class of potent inhibitors of osteoclastic bone resorption: D. Feuerbach, et al.; J. Biol. Chem. 270, 25949 (1995) Abstract; Full Text

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