ALEXIS Biochemicals: Antipain

ALX-260-093

Revised 22-May-06

Antipain
SYNONYMS	[(S)-1-Carboxy-2-phenylethyl]-carbamoyl-Arg-Val-arginal . 2HCl
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	Proteases Other Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-260-093-M005		5 mg	35.00 USD
ALX-260-093-M025		25 mg	130.00 USD

Product Specification

SEQUENCE:	[(S)-1-Carboxy-2-phenylethyl]-carbamoyl-Arg-Val-arginal
FORMULA:	C₂₇H₄₄N₁₀O₆ . 2HCl
MW:	604.7 . 73.0
CAS NUMBER:	37682-72-7
SOURCE/HOST:	Synthetic.
APPEARANCE:	White to off-white powder.
SOLUBILITY:	Soluble in water, methanol, 100 % ethanol or acetonitrile.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HANDLING:	Protect from light.

Product Description

Inhibits papain and trypsin and to a small extent plasmin. Antipain is more specific for papain and trypsin than is leupeptin (Prod. No. ALX-260-009). The inhibitory potency of antipain is 100-fold higher than that of elastatinal. Acts by forming a hemiacetal adduct between its aldehyde group and the active serine of the proteinase.

Product Specific Literature References

Antipain, a new protease inhibitor isolated from actinomycetes: H. Suda, et al.; J. Antibiot. 25, 263 (1972) Abstract
Structures and activities of protease inhibitors of microbial origin: H. Umezawa; Meth. Enzymol. 45, 678 (1976) Abstract

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