ALEXIS Biochemicals: Apoptosis Activator 2

ALX-420-035

Revised 03-May-05

Apoptosis Activator 2
SYNONYMS	1-[(3,4-Dichlorophenyl)methyl]-1H-indole-2,3-dione
PRODUCT LINE	Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY	Apoptosis Inducers & Inhibitors Other Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-420-035-M005		5 mg	45.00 USD
ALX-420-035-M025		25 mg	180.00 USD

Product Specification

FORMULA:	C₁₅H₉NO₂Cl₂
MW:	306.1
CAS NUMBER:	79183-19-0
PURITY:	≥98% (NMR)
APPEARANCE:	Orange to red solid.
SOLUBILITY:	Soluble in DMSO or 100% ethanol.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C

Product Description

Induces apoptosis by promoting the oligomerization of Apaf-1 into the mature, functional apoptosome, triggering caspase-9 activation resulting in activated caspase-3. Shows strong selectivity for cancer cells against normal cell lines. Acts in a similar way like apoptosis inducer PETCM (Prod. No. ALX-420-031).

Product Specific Literature References

Direct activation of the apoptosis machinery as a mechanism to target cancer cells: J.T. Nguyen and J.A. Wells; PNAS 100, 7533 (2003) Abstract; Full Text

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