ALEXIS Biochemicals: Apoptosis Inducer Set

ALX-850-235

Revised 29-May-08

Apoptosis Inducer Set
PRODUCT LINE	Cell Death / Apoptosis / Autophagy
PRODUCT CATEGORY	Apoptosis Inducers & Inhibitors Other Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-850-235-KI01		1 Set	315.00 USD

Product Specification

KIT/SET CONTAINS:	Contains 5 ready-to-use reagents: - Actinomycin D, 50µl (10mM), violet cap - Camptothecin, 1ml (2mM), red cap - Cycloheximide, 1ml (100mM), green cap - Dexamethasone, 1ml (10mM), blue cap - Etoposide, 100µl (100mM), yellow cap
FORMULATION:	Liquid. In DMSO
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C

Product Description

The set contains 5 ready-to-use reagents that induce apoptosis through different mechanisms. Actinomycin D, an antineoplastic antibiotic, inhibits RNA synthesis. Camptothecin, an inhibitor of nuclear topoisomerase, induces apoptosis in many types of cells. Cycloheximide, an active antibiotic against many yeast and fungi, inhibits protein synthesis. Dexamethasone, an active and highly stable glucocorticoid, probably induces apoptosis by binding and activating the intracellular glucocorticoid receptor. Etoposide, a derivative of podophyllotoxin, inhibits topoisomerase activity.

Product Specific Literature References

Topoisomerase inhibitors induce apoptosis in thymocytes: Y. Onishi, et al.; Biochim Biophys Acta 1175, 147 (1993) Abstract
Dexamethasone and etoposide induce apoptosis in rat thymocytes from different phases of the cell cycle: H.O. Fearnhead, et al.; Biochem. Pharmacol. 48, 1073 (1994) Abstract
Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: inhibition by overexpression of Bcl-2 and Abl: S.J. Martin, et al.; J. Exp. Med. 182, 1545 (1995) Abstract
Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis: D.W. Nicholson, et al.; Nature 376, 37 (1995) Abstract

General Information

BACKGROUND/TECHNICAL INFORMATION	We recommend using 1000x dilutions for inducing apoptosis in cell cultures. Optimal doses may vary for different cells and culture conditions and must be determined individually.
MANUFACTURER	Manufactured by BioVision.

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