ALEXIS Biochemicals: Arachidonoyl 2’-chloroethylamide

ALX-340-053

Revised 04-Aug-08

Arachidonoyl 2’-chloroethylamide
SYNONYMS	ACEA N-(2-Chloroethyl)-5Z,8Z,11Z,14Z-eicosatetraenamide
PRODUCT LINE	Neurobiology
PRODUCT CATEGORY	Anandamide & Anandamide Analogs

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-340-053-M005		5 mg	46.00 USD

Product Specification

FORMULA:	C₂₂H₃₆NOCl
MW:	366.0
CAS NUMBER:	220556-69-4
CONCENTRATION:	10mg/ml
PURITY:	≥96%
FORMULATION:	Liquid. Solution in methyl acetate.
SOLUBILITY:	20mg/ml soluble in 100% ethanol, DMSO or dimethyl formamide; 250μg/ml soluble in a 1:3 solution of ethanol:PBS (pH 7.2) (dilute the ethanol solution with PBS).
SHIPPING:	SHIPPED ON DRY ICE
LONG TERM STORAGE:	-80°C
USE/STABILITY:	Stable for at least 1 year after receipt when stored at -80°C. We do not recommend storing aqueous solutions for more than one day.

Product Description

Non-pungent, potent and highly selective CB₁ receptor agonist (K_i=1.4nM). Displays >1'400-fold selectivity over CB₂ receptors (K_i=3.1µM). Active in vivo.

Product Specific Literature References

Synthesis and characterization of potent and selective agonists of the neuronal cannabinoid receptor (CB1): C.J. Hillard, et al.; J. Pharmacol. Exp. Ther. 289, 1427 (1999) Abstract
Arachidonylcyclopropylamide increases microglial cell migration through cannabinoid CB2 and abnormal-cannabidiol-sensitive receptors: A. Franklin, et al.; Eur. J. Pharmacol. 474, 195 (2003) Abstract
Modulation of trigeminal sensory neuron activity by the dual cannabinoid-vanilloid agonists anandamide, N-arachidonoyl-dopamine and arachidonyl-2-chloroethylamide: T.J. Price, et al.; Br. J. Pharmacol. 141, 1118 (2004) Abstract
The cannabinomimetic arachidonyl-2-chloroethylamide (ACEA) acts on capsaicin-sensitive TRPV1 receptors but not cannabinoid receptors in rat joints: C.L. Baker and J.J. McDougall; Br. J. Pharmacol. 142, 1361 (2004) Abstract; Full Text

General Information

BACKGROUND/TECHNICAL INFORMATION

To change the solvent, evaporate the methyl acetate under a gentle stream of nitrogen and immediately add the solvent of choice.

Further Categories Containing This Product:

Cannabinoid Receptor Agonists & Antagonists / Related Products

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