ALEXIS Biochemicals: Arcyriaflavin A

ALX-350-375

Revised 22-Jul-08

Arcyriaflavin A
PRODUCT LINE	Cell Cycle
PRODUCT CATEGORY	CDK & Cyclin Inhibitors

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-350-375-M001		1 mg	160.00 USD

Product Specification

FORMULA:	C₂₀H₁₁N₃O₂
MW:	325.3
CAS NUMBER:	118458-54-1
SOURCE/HOST:	Synthetic. Originally isolated from the marine ascidian Eudistoma sp.
PURITY:	≥95% (HPLC)
APPEARANCE:	Orange to red solid.
SOLUBILITY:	Soluble in DMSO (50mg/ml).
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Stock solutions are stable for up to 3 months at -20°C.
HANDLING:	After reconstitution, prepare aliquots and store at -20°C. Protect from light. Packaged under inert gas.

Product Description

Potent inhibitor of CDK4 / cyclin D1 (IC₅₀= 59nM). Inhibits human cytomegalovirus (HCMV) replication in cell culture (IC₅₀ = 200nM).

Product Specific Literature References

Staurosporine aglycone (K252-c) and arcyriaflavin A from the marine ascidian, Eudistoma sp: P.A. Horton, et al.; Experientia 50, 843 (1994) Abstract
Indolocarbazoles: potent, selective inhibitors of human cytomegalovirus replication: M.J. Slater, et al.; Bioorg. Med. Chem. 7, 1067 (1999) Abstract
Aryl[a]pyrrolo[3,4-c]carbazoles as selective cyclin D1-CDK4 inhibitors: C. Sanchez-Martinez, et al.; Bioorg. Med. Chem. Lett. 13, 3835 (2003) Abstract
Synthesis of quinolinyl/isoquinolinyl[a]pyrrolo [3,4-c] carbazoles as cyclin D1/CDK4 inhibitors: G. Zhu, et al.; Bioorg. Med. Chem. Lett. 13, 1231 (2003) Abstract
Two indolocarbazole alkaloids with apoptosis activity from a marine-derived actinomycete Z(2)039-2: R. Liu, et al.; Arch. Pharm. Res. 30, 270 (2007) Abstract

Further Categories Containing This Product:

Natural Products for Cell Cycle Research • Antiviral Agents Other Products • Marine Natural Products

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