ALEXIS Biochemicals: Artemisinin

ALX-350-219

Revised 28-May-08

Artemisinin
SYNONYMS	Qinghaosu
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Natural Products - Antimalarial Agents

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-350-219-M100		100 mg	35.00 USD
ALX-350-219-G001		1 g	220.00 USD

Product Specification

FORMULA:	C₁₅H₂₂O₅
MW:	282.4
CAS NUMBER:	63968-64-9
MERCK INDEX:	14: 817
SOURCE/HOST:	Isolated from the traditional Chinese anti-malarial herb Artemisia annua L.
PURITY:	≥98%
APPEARANCE:	White crystalline solid.
SOLUBILITY:	Soluble in methanol, 100% ethanol, dimethyl formamide, DMSO, chloroform or acetone; almost insoluble in water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HANDLING:	Protect from light and moisture.
HAZARD:	TOXIC.

Product Description

Powerful antimalarial agent. Inhibits angiogenesis by down-regulating HIF-1α and VEGF expression in mouse embryonic stem cells. Crosses the blood-brain barrier. Inhibitor of human iNOS (NOS II).

Product Specific Literature References

Qinghaosu (artemisinin): an antimalarial drug from China: D.L. Klayman; Science 228, 1049 (1985) Abstract
The chemistry, pharmacology, and clinical applications of qinghaosu (artemisinin) and its derivatives: X.D. Luo & C.C. Shen; Med. Res. Rev. 7, 29 (1987) Abstract
Inhibition of angiogenesis in embryoid bodies by artemisinin: M. Wartenberg, et al.; Pflugers Arch. Eur. J. Physiol. 445, S85 (1994)
Artemisinin drugs in the treatment of malaria: from medicinal herb to registered medication: M.A. van Agtmael, et al.; Trends Pharmacol. Sci. 20, 199 (1999), Review Abstract
Artemisinin inhibits inducible nitric oxide synthase and nuclear factor NF-kB activation: E. Aldieri, et al.; FEBS Lett. 552, 141 (2003) Abstract
The antimalaria agent artemisinin exerts antiangiogenic effects in mouse embryonic stem cell-derived embryoid bodies: M. Wartenberg, et al.; Lab. Invest. 83, 1647 (2003) Abstract
An over four millennium story behind qinghaosu (artemisinin)--a fantastic antimalarial drug from a traditional chinese herb: Y. Li & Y.L. Wu; Curr. Med. Chem. 10, 2197 (2003), Review Abstract
From artemisinin to new artemisinin antimalarials: biosynthesis, extraction, old and new derivatives, stereochemistry and medicinal chemistry requirements: R.K. Haynes; Curr. Top. Med. Chem. 6, 509 (2006), Review Abstract

Further Categories Containing This Product:

NOS Inhibitors (NOS Induction & Enzyme Activity) • Hypoxia-inducible Factor [HIF] / Related Products • Natural Products for Angiogenesis Research • Natural Products - Nitric Oxide Pathway Modulators • Malaria / Related Products

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