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ALX-380-108 Revised 03-Apr-08
Atpenin A5
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SYNONYMS 3-[(2S,4S,5R)-5,6-Dichloro-2,4-dimethyl-1-oxohexyl]-4-hydroxy-5,6-dimethoxy-2(1H)-pyridinone
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - Antifungal
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-380-108-C250   250 µg 90.00 USD Add To Cart
Product Specification
FORMULA: C15H21Cl2NO5
MW: 366.2
CAS NUMBER: 119509-24-9
RTECS: CJ8800000
SOURCE/HOST: Produced by Penicillium sp.
PURITY: ≥85% (HPLC)
APPEARANCE: Colorless oil.
SOLUBILITY: Soluble in DMSO, methanol or 100% ethanol; insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C

Product Description
Antibiotic. Potent and specific inhibitor of mitochondrial complex II (succinate-ubiquinone oxidoreductase).
Product Specific Literature References
Atpenins, new antifungal antibiotics produced by Penicillium sp. Production, isolation, physico-chemical and biological properties: S. Omura, et al.; J. Antibiot. 41, 1769 (1988) Abstract
The structures of atpenins A4, A5 and B, new antifungal antibiotics produced by Penicillium sp: H. Kumagai, et al.; J. Antibiot. 43, 1553 (1990) Abstract
Mechanism of action of atpenin B on Raji cells: K. Oshino, et al.; J. Antibiot. 43, 1064 (1990) Abstract
Atpenins, potent and specific inhibitors of mitochondrial complex II (succinate-ubiquinone oxidoreductase): H. Miyadera, et al.; PNAS 100, 473 (2003) Abstract
Structural and computational analysis of the quinone-binding site of complex II (succinate-ubiquinone oxidoreductase): a mechanism of electron transfer and proton conduction during ubiquinone reduction: R. Horsefield, et al.; J. Biol. Chem. 281, 7309 (2006) Abstract; Full Text
General Information
MANUFACTURER Fungal strain courtesy of the Kitasato Institute, Tokyo.
Further Categories Containing This Product:
Respiratory Chain Other Products
 
 
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