ALEXIS Biochemicals: Auraptene

ALX-350-361

Revised 17-Mar-08

Auraptene
SYNONYMS	7-Geranyloxycoumarin 7-[(2E)-3,7-Dimethylocta-2,6-dienoxy]chromen-2-one
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Natural Products - Chemopreventive Agents

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-350-361-M005		5 mg	25.00 USD
ALX-350-361-M025		25 mg	75.00 USD

Product Specification

FORMULA:	C₁₉H₂₂O₃
MW:	298.4
CAS NUMBER:	495-02-3
SOURCE/HOST:	Isolated from citrus fruit.
PURITY:	≥98% (HPLC)
SOLUBILITY:	Soluble in methanol or 100% ethanol.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
IDENTITY:	Identity determined by NMR.

Product Description

Anti-inflammatory and chemopreventive compound. Exerts tumor preventive effects through apoptosis. Suppresses cell proliferation and lipid peroxidation. Acts as an agonist of PPARs. Induces phase II drug-metabolizing enzymes.

Product Specific Literature References

Citrus auraptene exerts dose-dependent chemopreventive activity in rat large bowel tumorigenesis: the inhibition correlates with suppression of cell proliferation and lipid peroxidation and with induction of phase II drug-metabolizing enzymes: T. Tanaka, et al.; Cancer Res. 58, 2550 (1998) Abstract; Full Text
Immunomodulatory action of citrus auraptene on macrophage functions and cytokine production of lymphocytes in female BALB/c mice: T. Tanaka, et al.; Carcinogenesis 20, 1471 (1999) Abstract; Full Text
Cell proliferation in cancer prevention; effects of preventive agents on estrogen-related endometrial carcinogenesis model and on an in vitro model in human colorectal cells: H. Mori, et al.; Mutat. Res. 480-481, 201 (2001) Abstract
Synthesis and anti-inflammatory activity of natural and semisynthetic geranyloxycoumarins: M. Curini, et al.; Bioorg. Med. Chem. Lett. 14, 2241 (2004) Abstract
Citrus auraptene targets translation of MMP-7 (matrilysin) via ERK1/2-dependent and mTOR-independent mechanism: K. Kawabata, et al.; FEBS Lett. 580, 5288 (2006) Abstract
Citrus auraptene acts as an agonist for PPARs and enhances adiponectin production and MCP-1 reduction in 3T3-L1 adipocytes: K. Kuroyanagi, et al.; BBRC 366, 219 (2008) Abstract

Further Categories Containing This Product:

PPAR Agonists • Antitumor Agents (Apoptosis Inducers) • Natural Products - Anti-inflammatory Agents • Natural Products - Apoptosis Inducers & Inhibitors

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