ALEXIS Biochemicals: Aurintricarboxylic acid

ALX-270-201

Revised 18-Sep-07

Aurintricarboxylic acid
SYNONYMS	ATA
PRODUCT LINE	DNA Regulation / Transcription
PRODUCT CATEGORY	Topoisomerase Inhibitors Other Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-201-G001		1 g	15.00 USD

Product Specification

FORMULA:	C₂₂H₁₄O₉
MW:	422.4
CAS NUMBER:	4431-00-9
PURITY:	~85%
APPEARANCE:	Red solid.
SOLUBILITY:	Soluble in aqueous alkali.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+20°C
HAZARD:	IRRITANT.

Product Description

Potent inhibitor of DNA topoisomerase II in vitro and protein-nucleic acid interactions. Stimulates the tyrosine phosphorylation of MAP kinases. Inhibits both major calpain isoforms. Potent and selective inhibitor of SARS coronavirus replication. Apoptosis inhibitor.

Product Specific Literature References

Mechanism of action of polymeric aurintricarboxylic acid, a potent inhibitor of protein--nucleic acid interactions: R.G. Gonzalez, et al.; Biochemistry 19, 4299 (1980) Abstract
Delayed application of aurintricarboxylic acid reduces glutamate- induced cortical neuronal injury: C.A. Csernansky, et al.; J. Neurosci. Res. 38, 101 (1994) Abstract
Inhibition of topoisomerase II by aurintricarboxylic acid: implications for mechanisms of apoptosis: D.R. Catchpoole & B.W. Stewart; Anticancer Res. 14, 853 (1994) Abstract
Aurintricarboxylic acid, a putative inhibitor of apoptosis, is a potent inhibitor of DNA topoisomerase II in vitro and in Chinese hamster fibrosarcoma cells: Y. Benchokroun, et al.; Biochem. Pharmacol. 49, 305 (1995) Abstract
A neuroprotective compound, aurin tricarboxylic acid, stimulates the tyrosine phosphorylation cascade in PC12 cells: N. Okada & S. Koizumi; J. Biol. Chem. 270, 16464 (1995) Abstract; Full Text
Potent and selective inhibition of SARS coronavirus replication by aurintricarboxylic acid: R. He, et al.; BBRC 320, 1199 (2004) Abstract

Further Categories Containing This Product:

Apoptosis Inducers & Inhibitors Other Products

another CS2 website

Online Product Ordering

Clipboard [0]

Your items will be kept only for the duration of your visit.