ALEXIS Biochemicals: Australine . hydrochloride

ALX-270-157

Revised 03-Apr-08

Australine . hydrochloride
SYNONYMS	(1R,2R,3R,7S,7aR)-3-Hydroxymethyl-1,2,7-trihydroxypyrrolizidine . HCI
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Natural Products - Other Signal Transduction Pathway Modulators

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-157-M001		1 mg	180.00 USD

Product Specification

FORMULA:	C₈H₁₅NO₄. HCl
MW:	189.2 . 36.5
CAS NUMBER:	186766-07-4
SOURCE/HOST:	Isolated from Castanospermum australe seeds.
PURITY:	≥95%
APPEARANCE:	Crystalline solid.
SOLUBILITY:	Soluble in water, methanol and 100% ethanol.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C
HANDLING:	After reconstitution, prepare aliquots and store at -20°C.
HAZARD:	HARMFUL.

Product Description

Alkaloid. Inhibitor of α-glucosidase, amyloglucosidase and glucosidase I. Does not inhibit glucosidase II, and is reported to be the first glucosidase inhibitor which differentiates glucosidase I from glucosidase II. Does not inhibit α-galactosidase, β-galactosidase, β-glucosidase, α-mannosidase and β-mannosidase.

Product Specific Literature References

Australine, a pyrrolizidine alkaloid that inhibits amyloglucosidase and glycoprotein processing: J.E. Tropea, et al.; Biochemistry 28, 2027 (1989) Abstract
Calystegins, a novel class of alkaloid glycosidase inhibitors: R.J. Molyneux, et al.; Arch. Biochem. Biophys. 304, 81 (1993) Abstract
Stereoselective synthesis of the glycosidase inhibitor australine through a one-pot, double-cyclization strategy: C. Ribes, et al.; Org. Lett. 9, 77 (2007) Abstract

Further Categories Containing This Product:

Alkaloids • Glycosidases / Related Products

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