ALEXIS Biochemicals: BADGE

ALX-270-353

Revised 16-Feb-07

BADGE
SYNONYMS	Bisphenol A diglycidyl ether 2,2'-[(1-Methylethylidene)bis(4,1-phenyleneoxymethylene)]bis-oxirane
PRODUCT LINE	DNA Regulation / Transcription
PRODUCT CATEGORY	PPAR Antagonists

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-353-G025		25 g	19.00 USD

Product Specification

FORMULA:	C₂₁H₂₄O₄
MW:	340.4
CAS NUMBER:	1675-54-3
PURITY:	≥85%
FORMULATION:	Neat oil.
SOLUBILITY:	Miscible in organic solvents as 100% ethanol, DMSO or dimethyl formamide. Insoluble in PBS, pH 7.2.
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Stock solutions in 100% ethanol, DMSO or dimethyl formamide are stable for at least 1 year if stored at -20°C.

Product Description

Antagonist of PPARγ. Binds to PPARγ with an apparent K_d of 100µM.

Product Specific Literature References

A synthetic antagonist for the peroxisome proliferator-activated receptor gamma inhibits adipocyte differentiation: H.M. Wright, et al.; J. Biol. Chem. 275, 1873 (2000) Abstract; Full Text
Bisphenol A diglycidyl ether induces apoptosis in tumour cells independently of peroxisome proliferator-activated receptor-gamma, in caspase-dependent and -independent manners: S. Fehlberg, et al.; Biochem. J. 362, 573 (2002) Abstract; Full Text
Bisphenol a diglycidyl ether (BADGE) suppresses tumor necrosis factor-alpha production as a PPARgamma agonist in the murine macrophage-like cell line, RAW 264.7: M. Nakamuta, et al.; Cell Biol. Int. 26, 235 (2002) Abstract
Induction of apoptosis in human and rat glioma by agonists of the nuclear receptor PPARgamma: T. Zander, et al.; J. Neurochem. 81, 1052 (2002) Abstract

General Information

Interferes with the ability of 3T3-L1 and 3T3-F442A cells to undergo hormone-mediated cell differentiation.

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