ALEXIS Biochemicals: BAFF-R (human):Fc (human) (recombinant)

ALX-522-060

Revised 31-May-05

BAFF-R (human):Fc (human) (recombinant)
SYNONYMS	BR3 (human):Fc (human) (recombinant) BlySR3 (human):Fc (human) (recombinant) TNFRSF 13C (human):Fc (human) (recombinant) CD268 (human):Fc (human) (recombinant)
PRODUCT LINE	Chemokines & Cytokines
PRODUCT CATEGORY	BAFF-R

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-522-060-C050		50 µg	365.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Human Mouse
MW:	~40kDa (SDS-PAGE)
SOURCE/HOST:	Produced in HEK 293 cells. The extracellular domain of human BAFF-R (aa 2-71) is fused at the C-terminus to the Fc portion of human IgG1.
CONCENTRATION:	1mg/ml (after reconstitution)
PURITY:	≥95% (SDS-PAGE)
FORMULATION:	Lyophilized. Contains PBS.
ENDOTOXIN CONTENT:	<0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION:	Reconstitute with 50µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum or a carrier protein.
SPECIFICITY:	Binds human and mouse BAFF.
BIOLOGICAL ACTIVITY:	Inhibits rhsBAFF mediated splenocyte survival.
APPLICATION:	Detection of membrane-bound human and mouse BAFF in combination with PAb to human IgG1.
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Stable for at least 6 months after receipt when stored at -20°C.
HANDLING:	After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.

Product Images

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General Information

BAFF-R:Fc is 10-fold more efficacious than BCMA:Fc for blocking BAFF-induced B cell proliferation in vitro and for blocking BAFF-mediated survival of mouse splenic B lymphocytes in vivo. Thus BAFF-R:Fc becomes a promising therapeutic candidate as a BAFF-neutralizing compound in autoimmune disease intervention [1].
BACKGROUND/TECHNICAL INFORMATION	Swiss-Prot link Q96RJ3: BAFF-R (human) AfCS Siganlling Gateway link A002648: BAFF-R (mouse)
MANUFACTURER	Manufactured by Apotech Corporation.

General Literature References

[1] Comparison of soluble decoy IgG fusion proteins of BAFF-R and BCMA as antagonists for BAFF: M. Pelletier, et al.; J. Biol. Chem. 278, 33127 (2003) Abstract