ALEXIS Biochemicals: BAFF, Soluble (human) Detection Set [For ELISA Application]

APO-54N-022

Revised 01-Apr-08

BAFF, Soluble (human) Detection Set [For ELISA Application]
SYNONYMS	BLyS, Soluble (human) Detection Set [For ELISA Application] TALL-1, Soluble (human) Detection Set [For ELISA Application] zTNF4, Soluble (human) Detection Set [For ELISA Application] TNFSF 13B/20, Soluble (human) Detection Set [For ELISA Application] CD257, Soluble (human) Detection Set [For ELISA Application]
PRODUCT LINE	Chemokines & Cytokines
PRODUCT CATEGORY	BAFF

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
APO-54N-022-KI01		1 Set	560.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Human
SENSITIVITY:	0.3ng/ml (range 0 to 30ng/ml).
QUANTITY:	For 5x96 wells.
KIT/SET CONTAINS:	1 vial Standard (lyophilized) (STD) 1 vial Coating Antibody (COAT) 1 vial Detection Antibody (DET) 1 vial Goat anti-rat IgG-HRP (HRP)
APPLICATION:	For the quantitative determination of soluble human BAFF from biological fluids (serum and cell culture supernatant). Does not cross-react with mouse BAFF.
SHIPPING:	SHIPPED ON BLUE ICE
SHORT TERM STORAGE:	+4°C
LONG TERM STORAGE:	-20°C
HANDLING:	Avoid freeze/thaw cycles.

General Information

BAFF (B cell activation factor of the TNF family, also known as BLyS or TALL1) is a cytokine expressed predominantly by cells of the immune system such as neutrophils, monocytes, macrophages, dendritic cells, follicular dendritic cells, activated T cells and some malignant B cells. BAFF binds three distinct receptors (BAFF-R, TACI and BCMA) expressed predominantly on B cells, although activated T cells also express BAFF-R. BAFF is a master regulator of peripheral B cell survival, and also acts in processes such as immunoglobulin isotype switch and B cell co-stimulation. Besides its major role in B cell biology, BAFF co-stimulates activated T cells. Deregulated expression of this membrane-bound protein, which can readily be released in a soluble form, leads to autoimmune disorders in mice. In humans, elevated levels of soluble BAFF have been detected in the serum of patients with various autoimmune diseases.
BACKGROUND/TECHNICAL INFORMATION	Swiss-Prot link Q9Y275: BAFF (human)
MANUFACTURER	Manufactured by Apotech Corporation.

General Literature References

The TNF family members BAFF and APRIL: the growing complexity: F. Mackay & C. Ambrose; Cytokine Growth Factor Rev. 14, 311 (2003) Abstract
TNF deficiency fails to protect BAFF transgenic mice against autoimmunity and reveals a predisposition to B cell lymphoma: M. Batten, et al.; J. Immunol. 172, 812 (2004) Abstract
BAFF Augments Certain Th1-Associated Inflammatory Responses: A.P. Sutherland, et al.; J. Immunol. 174, 5537 (2005) Abstract; Full Text
The BAFF/APRIL system: life beyond B lymphocytes: L.G. Ng, et al.; Mol. Immunol. 42, 763 (2005) Abstract
The BAFF/APRIL system: an important player in systemic rheumatic diseases: F. Mackay, et al.; Curr. Dir. Autoimmun. 8, 243 (2005) Abstract

Further Categories Containing This Product:

another CS2 website

Online Product Ordering

Clipboard [0]

Your items will be kept only for the duration of your visit.