ALEXIS Biochemicals: BAFF, Soluble (human) ELISA Kit

APO-54N-020

Revised 28-Nov-08

BAFF, Soluble (human) ELISA Kit
SYNONYMS	BlyS, Soluble (human) ELISA Kit TALL-1, Soluble (human) ELISA Kit THANK, Soluble (human) ELISA Kit zTNF4, Soluble (human) ELISA Kit TNFSF 13B/20, Soluble (human) ELISA Kit CD257, Soluble (human) ELISA Kit
PRODUCT LINE	Chemokines & Cytokines
PRODUCT CATEGORY	BAFF

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
APO-54N-020-KI01		1 Kit	630.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Human
SENSITIVITY:	0.95ng/ml (range 0 to 128ng/ml)
QUANTITY:	For 96 wells (~80 tests)
APPLICATION:	For the quantitative determination of soluble human BAFF from biological fluids (serum and cell culture supernatant).
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	+4°C

Product Specific Literature References

High serum levels of BAFF, APRIL, and TACI in common variable immunodeficiency: A.K. Knight, et al.; Clin. Immunol. 124, 182 (2007) Abstract; Full Text

General Information

BAFF (B cell activating factor belonging to the TNF family, also known as BLyS or TALL1) is a cytokine expressed predominantly by cells of the immune system such as neutrophils, monocytes, macrophages, dendritic cells, follicular dendritic cells, activated T cells and some malignant B cells. BAFF binds three distinct receptors (BAFFR, TACI and BCMA) predominantly expressed on B cells, although activated T cells also express BAFFR. BAFF is a master regulator of peripheral B cell survival, and also acts in processes such as immunoglobulin isotype switch and B cell co-stimulation. Beside its major role in B cell biology, BAFF co-stimulates activated T cells. Deregulated expression of this membrane-bound protein, which can readily be released in a soluble form by proteolytic cleavage, leads to autoimmune disorders in mice. In the human, elevated levels of soluble BAFF have been detected in the serum of patients with various autoimmune diseases, such as rheumatoid arthritis (RA), Sjögren’s syndrome (SS) and systemic lupus erythematosus (SLE). BAFF levels are also elevated in patients with multiple myeloma and B-cell chronic lymphoid leukemia (B-CCL).
BACKGROUND/TECHNICAL INFORMATION	Swiss-Prot link Q9Y275: BAFF (human)
MANUFACTURER	Manufactured by Apotech Corporation & Immundiagnostik AG.

General Literature References

The BAFF/APRIL system: life beyond B lymphocytes: L.G. Ng, et al.; Mol. Immunol. 42, 763 (2005) Abstract
BAFF is produced by astrocytes and up-regulated in multiple sclerosis lesions and primary central nervous system lymphoma: M. Krumbholz, et al.; J. Exp. Med. 201, 195 (2005) Abstract

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