ALEXIS Biochemicals: BAFF, Soluble (human) (recombinant)

ALX-522-025

Revised 25-Aug-08

BAFF, Soluble (human) (recombinant)
SYNONYMS	BlyS, Soluble (human) (recombinant) TALL-1, Soluble (human) (recombinant) THANK, Soluble (human) (recombinant) zTNF4, Soluble (human) (recombinant) TNFSF 13B/20, Soluble (human) (recombinant) CD257, Soluble (human) (recombinant)
PRODUCT LINE	Chemokines & Cytokines
PRODUCT CATEGORY	BAFF

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-522-025-C010		10 µg	365.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Human Mouse
MW:	~28kDa (SDS-PAGE).
SOURCE/HOST:	Produced in E. coli. The extracellular domain of human BAFF (aa 83-285) is fused at the N-terminus to a linker peptide (6 aa) and a FLAG^®-tag.
CONCENTRATION:	0.1mg/ml after reconstitution.
PURITY:	≥95% (SDS-PAGE)
FORMULATION:	Lyophilized. Contains PBS.
ENDOTOXIN CONTENT:	<0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION:	Reconstitute with 100µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum.
SPECIFICITY:	Binds to human and mouse (weak) BCMA, TACI and BAFF-R.
BIOLOGICAL ACTIVITY:	Mediates splenocyte survival. Induces monocyte survival.
APPLICATION:	Detection of receptors of human soluble BAFF on target cells.
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Stable for at least 6 months after receipt when stored at -20°C.
HANDLING:	Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.

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Product Specific Literature References

BAFF binds to the tumor necrosis factor receptor-like molecule B cell maturation antigen and is important for maintaining the peripheral B cell population: J.S. Thompson, et al.; J. Exp. Med. 192, 129 (2000) Abstract; Full Text
BAFF mediates survival of peripheral immature B lymphocytes: M. Batten, et al.; J. Exp. Med. 192, 1453 (2000) Abstract; Full Text
Maturation of marginal zone and follicular B cells requires B cell activating factor of the tumor necrosis factor family and is independent of B cell maturation antigen: P. Schneider, et al.; J. Exp. Med. 194, 1691 (2001) Abstract
T cell costimulation by the TNF ligand BAFF: B. Huard, et al.; J. Immunol. 167, 6225 (2001) Abstract
Aberrant expression of B-lymphocyte stimulator by B chronic lymphocytic leukemia cells: a mechanism for survival: A.J. Novak, et al.; Blood 100, 2973 (2002) Abstract; Full Text
BAFF is a survival and maturation factor for mouse B cells: A.G. Rolink, et al.; Eur. J. Immunol. 32, 2004 (2002) Abstract
Expression of BLyS and its Receptors in B-Cell Non-Hodgkin Lymphoma: Correlation with Disease Activity and Patient Outcome: A.J. Novak, et al.; Blood 104, 2247 (2004) Abstract
TACI is mutant in common variable immunodeficiency and IgA deficiency: E. Castigli, et al.; Nat. Genet. 37, 829 (2005) Abstract
A role for BLyS in the activation of innate immune cells: S.K. Chang, et al.; Blood 108, 2687 (2006) Abstract; Full Text
Viral Double-Stranded RNA Triggers Ig Class Switching by Activating Upper Respiratory Mucosa B Cells through an Innate TLR3 Pathway Involving BAFF: W. Xu, et al.; J. Immunol. 181, 276 (2008) Abstract

General Information

BACKGROUND/TECHNICAL INFORMATION

Swiss-Prot link Q9Y275: BAFF (human)
AfCS Signalling Gateway link A000383: BAFF (mouse)

FLAG is a registered trademark of Sigma-Aldrich Co.

MANUFACTURER

Manufactured by Apotech Corporation.

General Literature References

TNFR-associated factor-3 is associated with BAFF-R and negatively regulates BAFF-R-mediated NF-kappa B activation and IL-10 production: L.G. Xu & H.B. Shu; J. Immunol. 169, 6883 (2002) Abstract; Full Text

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Recombinant Proteins / Fusion Proteins

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