ALEXIS Biochemicals: BAPTA/AM

ALX-450-014

Revised 22-Feb-08

BAPTA/AM
SYNONYMS	1,2-bis(2-Aminophenoxy)ethane-N,N,N',N'-tetraacetic acid tetrakis(acetoxymethyl) ester
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	Calcium Chelators/Caged Calcium Chelators

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-450-014-M010		10 mg	48.00 USD
ALX-450-014-M050		50 mg	195.00 USD

Product Specification

FORMULA:	C₃₄H₄₀N₂O₁₈
MW:	764.7
CAS NUMBER:	126150-97-8
PURITY:	≥98% (HPLC)
APPEARANCE:	White to off-white powder.
SOLUBILITY:	Soluble in DMSO (10mg/ml).
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HANDLING:	Packaged under inert gas. Protect from light and moisture.
HAZARD:	IRRITANT.
IDENTITY:	Determined by ¹H-NMR.

Product Description

Cell permeable acetoxymethyl ester derivative of BAPTA (Prod. No. ALX-450-013). Useful for controlling intracellular Ca²⁺ concentration. Induces inactivation of protein kinase C. Also inhibits thapsigargin-induced apoptosis in rat thymocytes.

Product Specific Literature References

Physiological [Ca2+]i level and pump-leak turnover in intact red cells measured using an incorporated Ca chelator: V.L. Lew, et al.; Nature 298, 478 (1982) Abstract
BAPTA induces a decrease of intracellular free calcium and a translocation and inactivation of protein kinase C in macrophages: P. Dieter, et al.; Biol. Chem. Hoppe-Seyler 374, 171 (1993) Abstract
Intracellular calcium chelator, BAPTA-AM, prevents cocaine-induced ventricular fibrillation: G.E. Billman; Am. J. Physiol. 265, H1529 (1993) Abstract
Intracellular Ca2+ signals activate apoptosis in thymocytes: studies using the Ca(2+)-ATPase inhibitor thapsigargin: S. Jiang, et al.; Exp. Cell. Res. 212, 84 (1994) Abstract
Stimulation of the ERK pathway by GTP-loaded Rap1 requires the concomitant activation of Ras, protein kinase C, and protein kinase A in neuronal cells: T. Bouschet, et al.; J. Biol. Chem. 278, 4778 (2003) Abstract; Full Text

Further Categories Containing This Product:

PKC Inhibitors • Apoptosis Inducers & Inhibitors Other Products • Nuclear Envelope & Nuclear Transport

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