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ALX-550-375 Revised 28-Jan-05
BRL 15572 . hydrochloride
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SYNONYMS 3-[4-(4-Chlorophenyl)piperazin-1-yl]-1,1-diphenyl-2-propanol . HCl
PRODUCT LINE Neurobiology
PRODUCT CATEGORY Serotonergics & Serotonin Receptors/Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-550-375-M005   5 mg 80.00 USD Add To Cart
Product Specification
FORMULA: C25H27ClN2O . HCl
MW: 406.9 . 36.5
CAS NUMBER: 193611-72-2
PURITY: ≥98%
APPEARANCE: White solid.
SOLUBILITY: Soluble in DMSO.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Description
Selective human 5-HT1D antagonist.
Product Specific Literature References
Stimulation of 5-HT1B receptors causes hypothermia in the guinea pig: J.J. Hagan, et al.; Eur. J. Pharmacol. 331, 169 (1997) Abstract
SB-216641 and BRL-15572-compounds to pharmacologically discriminate h5-HT1B and h5-HT1D receptors: G.W. Price, et al.; Naunyn Schmiedebergs Arch. Pharmacol. 356, 312 (1997) Abstract
Effects of selective h5-HT1B (SB-216641) and h5-HT1D (BRL-15572) receptor ligands on guinea-pig and human 5-HT auto- and heteroreceptors: E. Schlicker, et al.; Naunyn Schmiedebergs Arch. Pharmacol. 356, 321 (1997) Abstract
5-HT1-like receptors: a time to bid goodbye: P.R. Saxena, et al.; TIPS 19, 311 (1998), (Review) Abstract
The canine external carotid vasoconstrictor 5-HT1 receptor: blockade by 5-HT1B (SB224289), but not by 5-HT1D (BRL15572) receptor antagonists: P. De Vries, et al.; Eur. J. Pharmacol. 362, 69 (1998) Abstract
5-HT1B receptor-mediated contractions in human temporal artery: evidence from selective antagonists and 5-HT receptor mRNA expression: R. Verheggen, et al.; Br. J. Pharmacol. 124, 1345 (1998) Abstract
Pharmacological diversity between native human 5-HT1B and 5-HT1D receptors sited on different neurons and involved in different functions: M. Marcoli, et al.; Br. J. Pharmacol. 126, 607 (1999) Abstract
 
 
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