ALEXIS Biochemicals: Bafilomycin B1

ALX-380-063

Revised 03-Apr-08

Bafilomycin B1
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Antibiotics - ATPase Inhibitors

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-380-063-M001		1 mg	70.00 USD

Product Specification

FORMULA:	C₄₄H₆₅NO₁₃
MW:	816.0
CAS NUMBER:	88899-56-3; 80112-34-1
SOURCE/HOST:	Isolated from Streptomyces griseus.
PURITY:	≥95%
APPEARANCE:	Off-white to yellow powder.
SOLUBILITY:	Soluble in methanol.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HANDLING:	Protect from light.
HAZARD:	TOXIC.

Product Description

Macrolide antibiotic that acts as a specific inhibitor of vacuolar-type H⁺-ATPase.

Product Specific Literature References

Metabolic products of microorganisms. 224. Bafilomycins, a new group of macrolide antibiotics. Production, isolation, chemical structure and biological activity: G. Werner, et al.; J. Antibiot. (Tokyo) 37, 110 (1984) Abstract
Bafilomycins and concanamycins as inhibitors of V-ATPases and P-ATPases: S. Drose and K. Altendorf; J. Exp. Biol. 200, 1 (1997) Abstract
Biosynthetic investigations of the V-type ATPase inhibitors bafilomycin A1, B1 and concanamycin A: T. Schuhmann and S. Grond; J. Antibiot. (Tokyo) 57, 655 (2004) Abstract
Autophagy, bafilomycin and cell death: the "a-B-cs" of plecomacrolide-induced neuroprotection: J.J. Shacka, et al.; Autophagy 2, 228 (2006) Abstract

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