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ALX-550-237 Revised 18-Jan-05
Bepridil . hydrochloride
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SYNONYMS 1-Isobutoxy-2-pyrrolidino-3-(N-benzylanilino)propane . HCl
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Ca2+ Modulators
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-550-237-M010   10 mg 25.00 USD Add To Cart
ALX-550-237-M025   25 mg 55.00 USD Add To Cart
Product Specification
FORMULA: C24H34N2O . HCl
MW: 366.6 . 36.5
CAS NUMBER: 74764-40-2
MERCK INDEX: 14: 1150
PURITY: ≥98%
APPEARANCE: White solid.
SOLUBILITY: Soluble in 100% ethanol; insoluble in water.
SHIPPING: AMBIENT
LONG TERM STORAGE: +20°C
HANDLING: Store tightly sealed.

Product Description
Non-selective Ca2+ channel blocker. Stimulates the binding of 1,4-dihydropyridine-based drugs to Ca2+ channels. Inhibits Na+/Ca2+ exchange.
Product Specific Literature References
Characterization and photoaffinity labeling of receptor sites for the Ca2+ channel inhibitors d-cis-diltiazem, (+/-)-bepridil, desmethoxyverapamil, and (+)-PN 200-110 in skeletal muscle transverse tubule membranes: J.P. Galizzi, et al.; J. Biol. Chem. 261, 1393 (1986) Abstract; Full Text
Drug action and cellular calcium regulation: R. Janis, et al.; Adv. Drug Res. 16, 309 (1987)
Bepridil as an antisickling agent: membrane internalization and cell rigidity: R.M. Johnson, et al.; Am. J. Hematol. 46, 310 (1994) Abstract
Intracellular Ca2+ mediates the cytotoxicity induced by bepridil and benzamil in human brain tumor cells: Y.S. Lee, et al.; Cancer Lett. 88, 87 (1995) Abstract
 
 
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